ACVR1B antibody|ACVR1B抗体

货号： FNab00129 抗体名： anti- ACVR1B antibody 抗体英文名： anti- ACVR1B antibody 浓度： ≥95% as determined by SDS-PAGE 应用范围： ELISA, WB 宿主： Rabbit 供应商： 武汉菲恩生物科技有限公司 数量： 98 级别： 科研级别 保质期： 2年 -20℃ 适应物种： Human, Mouse 克隆性： 单克隆 保存条件： PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) 形态： liquid 亚型： IgG 免疫原： activin A receptor, type IB 规格： 100µg

ACVR1B antibody|ACVR1B抗体具有高亲合力和高特异性深受国外市场认可；菲恩生物专注于免疫学、细胞生物学、肿瘤、神经生物学等领域。
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产品介绍

品名	anti- ACVR1B antibody
货号	FNab00129
规格	100µg
状态	liquid
纯化方法	Immunogen affinity purified
纯度	≥95% as determined by SDS-PAGE
宿主	Rabbit
亚型	IgG
存储	PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.)
背景介绍	Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2(ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors(ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
免疫原	activin A receptor, type IB
别称	Activin A receptor, type IB, Activin receptor like kinase 4, Activin receptor type 1B, Activin receptor type IB, ACTR IB, ACTRIB, ACVR1B, ACVRLK4, ALK 4, ALK4, SKR2
分子量	50 kDa
Uniprot ID	P36896
适用种属	Human, Mouse
验证应用	ELISA, WB
建议稀释比例	WB: 1:200-1:2000
图片
		SW480 cells were subjected to SDS PAGE followed by western blot with FNab00129(ACVR1B Antibody) at dilution of 1:1000
注意事项	ACVR1B antibody|ACVR1B抗体仅供科研使用
产品链接	https://www.fn-test.cn/product/FNab00129/

菲恩简介
  菲恩生物面向国际市场专业研发，生产和销售ELISA试剂盒、抗体、重组蛋白及相关试剂,主要应用于免疫学、细胞生物学、肿瘤、神经生物学等相关领域的生命科学研究。

菲恩生物位置
  菲恩生物坐落于高新区、生物产业基地--武汉光谷生物城（biolake）。

菲恩优势
  1、专业科研试剂生产商，具有独立的现代化研发ZX和GMP标准的生产车间，产品高质控，高纯度，高活性，成本更低，价格竞争力强。
  2、专业科研试剂的研发，专注于免疫学、细胞生物学、肿瘤、神经生物学等领域，每年新增研发产品千余种。产品数量、批间批内差、亲合力、特异性达国际标准，
菲恩生物—科研好帮手，专业生产商。

研究领域
  免疫学、细胞生物学、肿瘤、神经生物学等相关领域的生命科学研究

质量保证
  菲恩生物建有现代化的研发ZX和符合GMP标准的生产车间，整体通过ISO 9001:2015质量管理体系认证。

产品数量
  ELISA试剂盒：18个种属：人、大鼠、小鼠、猪、牛、其他稀有种属
  主要指标：
    1、细胞因子：IL、Selectin、CSF、TNF、IF、TGF、chemokine、CAM、IGF、CR等；
    2、心肌梗塞：cTn，MYO，CRP等；
    3、内分泌：TH、Pg、Testosterone、GH、Cytokine receptor、Endothelin、COR、BGP、PRL、ACTH、FSH、Estradiol等；
    4、肝纤维化：HA、MMP、LN等；
    5、肿瘤标志物：TNF、TNFSF10、TNFRSF1A等；
    6、特种蛋白：Ig、CRP、ALB、FE、TRF等。
  抗体：兔多抗、鼠单抗种类丰富，一抗1万余种，二抗100多种；
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