品名 | anti- IGF1R antibody |
货号 | FNab04170 |
规格 | 100µg |
状态 | liquid |
纯化方法 | Immunogen affinity purified |
纯度 | ≥95% as determined by SDS-PAGE |
宿主 | Rabbit |
亚型 | IgG |
存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) |
背景介绍 | IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cell. IGF1R is a heterotetrameric receptor, composed of two alpha subunits (130 kDa each) and two beta subunits (~98 kDa each) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds. |
免疫原 | insulin-like growth factor 1 receptor |
别称 | CD221, IGFIR, IGFR, JTK13 |
分子量 | 70 kDa,90-100 kDa, 130 kDa |
Uniprot ID | P08069 |
适用种属 | Human, Mouse, Rat |
验证应用 | ELISA, WB, IHC, IF |
建议稀释比例 | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
图片 | | Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab04170(IGF1R-Specific antibody) at dilution of 1:100 |
| MCF7 cells were subjected to SDS PAGE followed by western blot with FNab04170(IGF1R-Specific antibody) at dilution of 1:1000 |
注意事项 | IGF1R antibody|IGF1R抗体仅供科研使用 |
产品链接 | https://www.fn-test.cn/product/FNab04170/ |