MAPKAPK2 antibody|MAPKAPK2抗体

货号： FNab04998 抗体名： anti- MAPKAPK2 antibody 抗体英文名： anti- MAPKAPK2 antibody 浓度： ≥95% as determined by SDS-PAGE 应用范围： ELISA, WB, IHC 宿主： Rabbit 供应商： 武汉菲恩生物科技有限公司 数量： 98 级别： 科研级别 保质期： 2年 -20℃ 适应物种： Human, Mouse 克隆性： 单克隆 保存条件： PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) 形态： liquid 亚型： IgG 免疫原： mitogen-activated protein kinase-activated protein kinase 2 规格： 100µg

MAPKAPK2 antibody|MAPKAPK2抗体具有高亲合力和高特异性深受国外市场认可；菲恩生物专注于免疫学、细胞生物学、肿瘤、神经生物学等领域。
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产品介绍

品名	anti- MAPKAPK2 antibody
货号	FNab04998
规格	100µg
状态	liquid
纯化方法	Immunogen affinity purified
纯度	≥95% as determined by SDS-PAGE
宿主	Rabbit
亚型	IgG
存储	PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.)
背景介绍	Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein(sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor(TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements(AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites(PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD4 mRNA. Involved in toll-like receptor signaling pathway(TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.
免疫原	mitogen-activated protein kinase-activated protein kinase 2
别称	MAPKAP kinase 2, MAPKAPK 2, MAPKAPK2, MK2
分子量	47-50 kDa
Uniprot ID	P49137
适用种属	Human, Mouse
验证应用	ELISA, WB, IHC
建议稀释比例	WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500
图片		Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab04998(MAPKAPK2 Antibody) at dilution of 1:50
		HeLa cells were subjected to SDS PAGE followed by western blot with FNab04998(MAPKAPK2 antibody) at dilution of 1:1000
注意事项	MAPKAPK2 antibody|MAPKAPK2抗体仅供科研使用
产品链接	https://www.fn-test.cn/product/FNab04998/

菲恩简介
  菲恩生物面向国际市场专业研发，生产和销售ELISA试剂盒、抗体、重组蛋白及相关试剂,主要应用于免疫学、细胞生物学、肿瘤、神经生物学等相关领域的生命科学研究。

菲恩生物位置
  菲恩生物坐落于高新区、生物产业基地--武汉光谷生物城（biolake）。

菲恩优势
  1、专业科研试剂生产商，具有独立的现代化研发ZX和GMP标准的生产车间，产品高质控，高纯度，高活性，成本更低，价格竞争力强。
  2、专业科研试剂的研发，专注于免疫学、细胞生物学、肿瘤、神经生物学等领域，每年新增研发产品千余种。产品数量、批间批内差、亲合力、特异性达国际标准，
菲恩生物—科研好帮手，专业生产商。

研究领域
  免疫学、细胞生物学、肿瘤、神经生物学等相关领域的生命科学研究

质量保证
  菲恩生物建有现代化的研发ZX和符合GMP标准的生产车间，整体通过ISO 9001:2015质量管理体系认证。

产品数量
  ELISA试剂盒：18个种属：人、大鼠、小鼠、猪、牛、其他稀有种属
  主要指标：
    1、细胞因子：IL、Selectin、CSF、TNF、IF、TGF、chemokine、CAM、IGF、CR等；
    2、心肌梗塞：cTn，MYO，CRP等；
    3、内分泌：TH、Pg、Testosterone、GH、Cytokine receptor、Endothelin、COR、BGP、PRL、ACTH、FSH、Estradiol等；
    4、肝纤维化：HA、MMP、LN等；
    5、肿瘤标志物：TNF、TNFSF10、TNFRSF1A等；
    6、特种蛋白：Ig、CRP、ALB、FE、TRF等。
  抗体：兔多抗、鼠单抗种类丰富，一抗1万余种，二抗100多种；
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