品名 | anti- TRIM25 antibody |
货号 | FNab08976 |
规格 | 100µg |
状态 | liquid |
纯化方法 | Immunogen affinity purified |
纯度 | ≥95% as determined by SDS-PAGE |
宿主 | Rabbit |
亚型 | IgG |
存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) |
背景介绍 | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma(SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3(PubMed:22452784). |
免疫原 | tripartite motif-containing 25 |
别称 | EFP,RING finger protein 147, RNF147, TRIM25, tripartite motif containing 25, Z147, Zinc finger protein 147, ZNF147 |
分子量 | 116 kDa |
Uniprot ID | Q14258 |
适用种属 | Human, Mouse |
验证应用 | ELISA, WB, IF, IP |
建议稀释比例 | WB: 1:200-1:2000; IP: 1:200-1:2000; IF: 1:20-1:200 |
图片 | |
| MCF7 cells were subjected to SDS PAGE followed by western blot with FNab08976(TRIM25 antibody) at dilution of 1:500 |
注意事项 | TRIM25 antibody|TRIM25抗体仅供科研使用 |
产品链接 | https://www.fn-test.cn/product/FNab08976/ |