品名 | anti- WTAP antibody |
货号 | FNab09530 |
规格 | 100µg |
状态 | liquid |
纯化方法 | Protein A+G purification |
纯度 | ≥95% as determined by SDS-PAGE |
宿主 | Mouse |
亚型 | IgG1 |
存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) |
背景介绍 | Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724). |
免疫原 | Wilms tumor 1 associated protein |
别称 | DKFZp686F20131, Female lethal(2)D homolog, hFL(2)D, KIAA0105, WT1 associated protein, WTAP |
分子量 | 49 kDa |
Uniprot ID | Q15007 |
适用种属 | Human, Mouse, Rat |
验证应用 | ELISA, WB, IHC |
建议稀释比例 | WB: 1:1000-1:10000; IHC: 1:50-1:500 |
图片 | | Immunohistochemistry of paraffin-embedded human cervical cancer using FNab09530(WTAP antibody) at dilution of 1:50 |
| HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab09530(WTAP Antibody) at dilution of 1:2000 |
注意事项 | WTAP antibody|WTAP抗体仅供科研使用 |
产品链接 | https://www.fn-test.cn/product/FNab09530/ |