重组人ERK1/MAPK3活性酶

产品英文名称：
Recombinant Human ERK1/MAPK3 Active Enzyme

英文简称:
ERK1/MAPK3

中文名称:
重组人ERK1/MAPK3活性酶

背景资料:
Extracellular signal-regulated kinases （ERKs） or classical MAP kinases are widely expressed protein kinaseintracellular signalingmolecules which are involved in functions including the regulation of meiosis， mitosis， and postmitotic functions in di大肠杆菌中重组表达erentiated cells. Many di大肠杆菌中重组表达erent stimuli， including growth factors， cytokines， virusinfection， ligands for heterotrimeric G protein-coupled receptors， transforming agents， and carcinogens， activate the ERK pathway.The term， "extracellular signal-regulated kinases"， is sometimes used as a synonym for mitogen-activated protein kinase（MAPK）， but has more recently bERK1/MAPK3 Recombinant is a highly active form produced by phosphorylation of the purified ERK1/MAPK3 in vitro with MEK1 is a non-glycosylated polypeptide having a molecular mass of 43.6 kDa.ERK1/MAPK3 is purified by proprietary chromatographic techniques.n adopted for a specific subset of the mammalianMAPK family. In the MAPK/ERK pathway， Rasactivates c-Raf， followed by MEKand then MAPK1/2 （below）. Ras is typically activated by growth hormones through receptor tyrosine kinasesand GRB2/SOS， but may also receive other signals. ERKs are known to activate many transcription factors and some downstream protein kinases. Disruption of the ERK pathway is common in cancers， especially Ras， c-Raf and receptors such as HER2.Mitogen-activated protein kinase 3 （MAPK3） is also known as "extracellular signal-regulated kinase 1" （ERK1）. Transgenic gene knockoutmice lacking MAPK3 are viable and it is thought that MAPK1 can fulfill most MAPK3 functions in most cells. The main exception is in T cells. Mice lacking MAPK3 have reduced T cell development past the CD4+CD8+ stage.

产品描述:
ERK1/MAPK3 Recombinant is a highly active form produced by phosphorylation of the purified ERK1/MAPK3 in vitro with MEK1 is a non-glycosylated polypeptide having a molecular mass of 43.6 kDa.ERK1/MAPK3 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:


溶解建议:
提供的人ERK1/MAPK3活性酶（ERK1/MAPK3）产品为过滤灭菌的透明溶液；其中0.15mg/ml人ERK1/MAPK3活性酶（ERK1/MAPK3）产品溶解于50mM Tris-HCl，150mM NaCl，1mM DTT，50%甘油，pH 8.5溶液中.

保存建议：
人ERK1/MAPK3活性酶（ERK1/MAPK3）溶液可以在4℃冷藏保存2-4周；如果想延长保存时间，建议分装后置于-20℃冻存.请避免反复冻融.
其他简介：

  ProSpec是一家细胞因子蛋白及相关抗体生产和研发品Pai。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种Z多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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