重组人HSP90ATP酶激活因子1

产品英文名称：
Recombinant Human Zinc-Alpha 2 Glycoprotein

英文简称:
ZA2G

中文名称:
重组人锌α2糖蛋白

背景资料:
Zinc-alpha-2-glycoprotein （ZAG） is found in body fluids such as serum， sweat， and seminal and breast cyst fluids. It is identical in amino acid sequence to tumor-derived lipid mobilizing factor （LMF）， a protein associated with the dramatic loss of adipose body stores in cancer cachexia， and has bZA2G Human Recombinant produced in HEK cells is a single， glycosylated polypeptide chain containing a total of 290 amino acids encoding （13-290）. ZA2G Human Recombinant is identical to Swiss-Prot-P25311 （AA 18-295， mature Zinc-Alpha-2-Glycoprotein）. Twelve extra amino acids were fused with the N-terminus （bold）.ASWSHPQFEK GSQENQDGRY SLTYIYTGLS KHVEDVPAFQ ALGSLNDLQF FRYNSKDRKS QPMGLWRQVEGMEDWKQDSQ LQKAREDIFM ETLKDIVEYY NDSNGSHVLQ GRFGCEIENN RSSGAFWKYY YDGKDYIEFNKEIPAWVPFD PAAQITKQKW EAEPVYVQRA KAYLEEECPA TLRKYLKYSK NILDRQDPPS VVVTSHQAPG EKKKLKCLAYDFYPGKIDVH WTRAGEVQEP ELRGDVLHNG NGTYQSWVVV AVPPQDTAPY SCHVQHSSLA QPLVVPWEAS.n shown to stimulate lipolysis by adipocytes in vivo and in vitro. A role for ZAG has bZA2G Human Recombinant produced in HEK cells is a single， glycosylated polypeptide chain containing a total of 290 amino acids encoding （13-290）. ZA2G Human Recombinant is identical to Swiss-Prot-P25311 （AA 18-295， mature Zinc-Alpha-2-Glycoprotein）. Twelve extra amino acids were fused with the N-terminus （bold）.ASWSHPQFEK GSQENQDGRY SLTYIYTGLS KHVEDVPAFQ ALGSLNDLQF FRYNSKDRKS QPMGLWRQVEGMEDWKQDSQ LQKAREDIFM ETLKDIVEYY NDSNGSHVLQ GRFGCEIENN RSSGAFWKYY YDGKDYIEFNKEIPAWVPFD PAAQITKQKW EAEPVYVQRA KAYLEEECPA TLRKYLKYSK NILDRQDPPS VVVTSHQAPG EKKKLKCLAYDFYPGKIDVH WTRAGEVQEP ELRGDVLHNG NGTYQSWVVV AVPPQDTAPY SCHVQHSSLA QPLVVPWEAS.n proposed in the regulation of body weight， and age-dependent changes in genetically influenced obesity， and also it regulates melanin production by normal and malignant melanocytes. It has also recently bZA2G Human Recombinant produced in HEK cells is a single， glycosylated polypeptide chain containing a total of 290 amino acids encoding （13-290）. ZA2G Human Recombinant is identical to Swiss-Prot-P25311 （AA 18-295， mature Zinc-Alpha-2-Glycoprotein）. Twelve extra amino acids were fused with the N-terminus （bold）.ASWSHPQFEK GSQENQDGRY SLTYIYTGLS KHVEDVPAFQ ALGSLNDLQF FRYNSKDRKS QPMGLWRQVEGMEDWKQDSQ LQKAREDIFM ETLKDIVEYY NDSNGSHVLQ GRFGCEIENN RSSGAFWKYY YDGKDYIEFNKEIPAWVPFD PAAQITKQKW EAEPVYVQRA KAYLEEECPA TLRKYLKYSK NILDRQDPPS VVVTSHQAPG EKKKLKCLAYDFYPGKIDVH WTRAGEVQEP ELRGDVLHNG NGTYQSWVVV AVPPQDTAPY SCHVQHSSLA QPLVVPWEAS.n classified as a novel adipokine in that it is produced by both white and brown fat adipocytes and may act in a local autocrine fashion in the reduction of adiposity in cachexia. Controlling ZAG/LMF’s activity could be life-saving in the management of certain cancers and other cachexiainducing conditions， and its possible normal role in body fat store homeostasis is deserving of understanding in its own right. ZAG exhibits a class I major histocompatibility complex （MHC） fold but is a soluble protein rather than being anchored to plasma membranes and does not associate with alpha-2-microglobulin in humans. Like antigen-presenting MHC class I proteins， ZAG has an open apical groove， and X-ray crystallography of human derived ZAG revealed an unidentifiable electron density in a similar position to that occupied by antigenic peptides in classical MHC proteins and glycolipids in isoforms of CD1. This presumptive ligand is not a peptide， and the groove is too small to hold a glycolipid such as is presented by CD1 isoforms. By analogy with all other MHC class I-related proteins that have an open apical groove [some do not ]， occupancy by a ligand is probably crucial to ZAG’s biological function. Despite all of the structural and biochemical evidence that ZAG binds a ligand， none has so far bZA2G Human Recombinant produced in HEK cells is a single， glycosylated polypeptide chain containing a total of 290 amino acids encoding （13-290）. ZA2G Human Recombinant is identical to Swiss-Prot-P25311 （AA 18-295， mature Zinc-Alpha-2-Glycoprotein）. Twelve extra amino acids were fused with the N-terminus （bold）.ASWSHPQFEK GSQENQDGRY SLTYIYTGLS KHVEDVPAFQ ALGSLNDLQF FRYNSKDRKS QPMGLWRQVEGMEDWKQDSQ LQKAREDIFM ETLKDIVEYY NDSNGSHVLQ GRFGCEIENN RSSGAFWKYY YDGKDYIEFNKEIPAWVPFD PAAQITKQKW EAEPVYVQRA KAYLEEECPA TLRKYLKYSK NILDRQDPPS VVVTSHQAPG EKKKLKCLAYDFYPGKIDVH WTRAGEVQEP ELRGDVLHNG NGTYQSWVVV AVPPQDTAPY SCHVQHSSLA QPLVVPWEAS.n found by extraction from protein isolated from biological fluids. This diHEK293人胚肾上皮细胞中重组表达iculty could be because the ligand is labile， heterogeneous， or readily lost during purification procedures. Knowing more about how ZAG interacts with the compounds it has bZA2G Human Recombinant produced in HEK cells is a single， glycosylated polypeptide chain containing a total of 290 amino acids encoding （13-290）. ZA2G Human Recombinant is identical to Swiss-Prot-P25311 （AA 18-295， mature Zinc-Alpha-2-Glycoprotein）. Twelve extra amino acids were fused with the N-terminus （bold）.ASWSHPQFEK GSQENQDGRY SLTYIYTGLS KHVEDVPAFQ ALGSLNDLQF FRYNSKDRKS QPMGLWRQVEGMEDWKQDSQ LQKAREDIFM ETLKDIVEYY NDSNGSHVLQ GRFGCEIENN RSSGAFWKYY YDGKDYIEFNKEIPAWVPFD PAAQITKQKW EAEPVYVQRA KAYLEEECPA TLRKYLKYSK NILDRQDPPS VVVTSHQAPG EKKKLKCLAYDFYPGKIDVH WTRAGEVQEP ELRGDVLHNG NGTYQSWVVV AVPPQDTAPY SCHVQHSSLA QPLVVPWEAS.n found to bind， both natural and artificial， will inform searches for the elusive ligand（s） and its/their role in ZAG’s signaling function.

产品描述:
ZA2G Human Recombinant produced in HEK cells is a single， glycosylated polypeptide chain containing a total of 290 amino acids encoding （13-290）. ZA2G Human Recombinant is identical to Swiss-Prot-P25311 （AA 18-295， mature Zinc-Alpha-2-Glycoprotein）. Twelve extra amino acids were fused with the N-terminus （bold）.ASWSHPQFEK GSQENQDGRY SLTYIYTGLS KHVEDVPAFQ ALGSLNDLQF FRYNSKDRKS QPMGLWRQVEGMEDWKQDSQ LQKAREDIFM ETLKDIVEYY NDSNGSHVLQ GRFGCEIENN RSSGAFWKYY YDGKDYIEFNKEIPAWVPFD PAAQITKQKW EAEPVYVQRA KAYLEEECPA TLRKYLKYSK NILDRQDPPS VVVTSHQAPG EKKKLKCLAYDFYPGKIDVH WTRAGEVQEP ELRGDVLHNG NGTYQSWVVV AVPPQDTAPY SCHVQHSSLA QPLVVPWEAS.
来源宿主:
HEK293人胚肾上皮细胞中重组表达

序列:


溶解建议:
Filtered White lyophilized （freeze-dried） powder. Filtered （0.4 um） and lyophilized in 0.5 mg/ml in 0.1M Tris-HCl pH 8.0 and 150mM NaCl. Add deionized water to a working concentration approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely.

保存建议：
Lyophilized ZA2G although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution ZA2G should be stored at 4℃ between 2-7 days and for future use below-18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.Please avoid freeze-thaw cycles.
其他简介：

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