重组人蛋白酪氨酸磷酸酯酶非受体1型

产品英文名称：
Recombinant Human Protein Tyrosine Phosphatase Non Receptor Type-1

英文简称:
PTPN1

中文名称:
重组人蛋白酪氨酸磷酸酯酶非受体1型

背景资料:
Protein Tyrosine Phosphatase 1B is the founding member of the protein tyrosine phosphatase （PTP） family， which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif， which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth， di大肠杆菌中重组表达erentiation， mitotic cycle， and oncogenic transformation. This PTP has bProtein Tyrosine Phosphatase Non Receptor Type-1 Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 321 amino acids and having a molecular mass of 37.3 kDa.n shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase， as well as JAK2 and TYK2 kinases， which implicated the role of this PTP in cell growth control， and cell response to interferon stimulation.

产品描述:
Protein Tyrosine Phosphatase Non Receptor Type-1 Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 321 amino acids and having a molecular mass of 37.3 kDa.
来源宿主:
大肠杆菌中重组表达

序列:
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溶解建议:
提供的人蛋白酪氨酸磷酸酯酶非受体1型（PTPN1）产品为过滤灭菌的无色溶液；其中人蛋白酪氨酸磷酸酯酶非受体1型（PTPN1）产品溶解于25mM Tris-HCl，pH 7.5，2mM 巯基乙醇，1mM EDTA，1mMDTT，20%甘油溶液中.

保存建议：
人蛋白酪氨酸磷酸酯酶非受体1型（PTPN1）溶液可以在4℃冷藏保存2-4周；如果想延长保存时间，建议分装（加载体蛋白如0.1% HSA或 BSA）后置于-20℃冻存.请避免反复冻融.
其他简介：

  ProSpec是一家细胞因子蛋白及相关抗体生产和研发品Pai。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种Z多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。