Acetylated tubulin (Lys40)抗体| Acetylated tubulin (Lys40) antibody

货号  PAab00082

蛋白别名  Acetylated alpha tubulin antibody, Acetylated tubulin antibody, acetylated-a-tubulin antibody, acetyl-a-tubulin antibody, alpha tubulin antibody, Alpha tubulin 3 antibody, tubulin antibody,TUBA1A

蛋白介绍

Tubulin, composed of heterodimers of alpha and beta tubulin, is the mainly component of microtubules which play important roles in cell motility, mitosis, and intracellular vesicle transport. Both alpha and beta tubulin undergo several posttranslational modifications such as polyglutamylation and acetylation/deacetylation. Tubulin acetylation occurs on lysine-40 at the N-terminal of alpha tubulin and is conserved across species. The histone deacetylase HDAC6 and SIRT2 has been identified as tubulin deacetylases. Reversible acetylation of alpha tubulin may be implicated in regulating microtubule stability, cell motility, and axon regeneration. The level of acetylated tubulin has been linked to epithelial malignancies and sensitivity to chemotherapy. In addition, acetylated tubulin has been widely used as a marker for primary cilia. This antibody is specific to the acetylated tubulin; it does not recognize non-acetylated tubulin.

产品描述

建议稀释比例

WB :1:500-1:5000;IF:1:20-1:200;IHC:1:20-1:200

IHC

human lung cancer tissue slide using PAab00082( TUBA1A(ace-40Lys) Antibody) at dilution of 1:50

Western blot

L02 cells were subjected to SDS PAGE followed by western blot with PAab00082( TUBA1A(ace-40Lys) Antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!)

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