ferritin heavy chain fragment [Multiple species]

产品描述
Sequence: H2N-YLNEQVKAI-OHThe two heavy chains are colored red and blue and the two light chains green and yellow.Ferritin is a protein of 450 kDa consisting of 24 subunits that is present in every cell type.In vertebrates, these subunits are both the light (L) and the heavy (H) type with an apparent molecular weight of 19 kDA or 21 kDA respectively; their sequences are about 50% homologous. [1] Heart, kidney, and placental ferritins are highly acidic because they are composed of mostly H chains[2]. The ferritin found in cancer cells was found to consist mainly of H chains[3][4].The heavy chain of Ferritin also possessesferroxidaseactivity, this involves the conversion of iron from the ferrous (Fe2+) to ferric (Fe 3+) forms. This limits the deleterious reaction which occurs between ferrous iron andhydrogen peroxideknown as theFenton reactionwhich produces the highly damaginghydroxyl radical.If the ferritin level is low, there is a risk for lack of iron, which could lead toanemia.[5] If ferritin is high, there is iron in excess or else there is an acute inflammatory reaction in which ferritin is mobilized without iron excess. For example, ferritins may be high in infection without signalling body iron overload. Ferritin is also used as amarkerforiron overload disorders, such as hemochromatosisorhemosiderosis.[6] Recent research has shown that H-Ferritin from melanoma cells may suppress immune responses.[7]Ref:1. Theil, E. (1987). "Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms."Annual review of biochemistry56(1): 289–315. doi:10.1146/annurev.bi.56.070187.001445.PMID3304136.2. Morikawa K., Oseko F., Morikawa S. A role for ferritin in hematopoiesis and the immune system.Leuk. Lymphoma,18:429-433,1995.3. Hazard J. T., Drysdale J. W. ferritinaemia in cancer.Nature (Lond.),265:755-756,1977.4. Constanzo F., Colombo M., Staempfli S., Santoro C., Marone M., Frank R., Delius H., Cortese R. Structure of gene and pseudogenes of human apoferritin H.Nucleic Acids Res.,14:721-736,1986.5. Guyatt G, Patterson C, Ali M, Singer J, Levine M, Turpie I, Meyer R (1990). "Diagnosis of iron-deficiency anemia in the elderly".Am J Med88(3): 205–9.doi:10.1016/0002-9343(90)90143-2.PMID2178409.6. Kennedy A, Kohn M, Lammi A, Clarke S (2004). "Iron status and haematological changes in adolescent female inpatients with anorexia nervosa".J Paediatr Child Health40(8): 430–2.doi:10.1111/j.1440-1754.2004.00432.x.PMID15265182.7. Gray C. P., Franco A. V., Arosio P., Hersey P. Immunosuppressive effects of melanoma-derived heavy-chain ferritinare dependent on stimulation of IL-10 production.Int. J. Cancer,92:843-850,2001.

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