Anti-CRK antibody

Anti-CRK antibody

Cat. No.     JC222151
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CRK rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human CRK
Reactivity                 Human, Mouse, Rat
Content                     0.4 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 CRK
Full name                 v-crk avian sarcoma virus CT10 oncogene homolog
Synonyms    p38; CRKII
Swissprot    P46108

Target Background
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human colon cancer
Recommended dilution: 50-200