FITC标记的磷酸化干扰素alpha/beta 受体1蛋白抗体_详细资料

产品信息

货号： LM-15522R-FITC 保存条件： -20 °C 浓度： 1mg/ml 应用范围： ICC=1:50-200 IF=1:50-200 形态：粉末、液体、冻干粉亚型： IGg 免疫原：详见说明书适应物种： Human, Pig, Horse, 宿主： Human, Pig, Horse, 标记物： FITC标记抗体名： Anti-phospho-IFNAR1(Tyr466) /FITC 抗体英文名： Anti-phospho-IFNAR1(Tyr466) /FITC 保质期： 1年抗原来源： Rabbit 克隆性：多克隆目录编号： LM-15522R-FITC 级别： 1 靶点：详见说明书数量：大量供应商：上海联迈生物工程有限公司规格： 100ul

FITC标记的磷酸化干扰素alpha/beta 受体1蛋白抗体

英文名称 Anti-phospho-IFNAR1(Tyr466) /FITC

中文名称 FITC标记的磷酸化干扰素alpha/beta 受体1蛋白抗体

别    名 IFNAR1 (phospho Y466); p-IFNAR1 (phospho Y466); Alpha type antiviral protein; AVP; Beta type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; IFN alpha REC; IFN alpha REC; IFN alpha receptor; IFN alpha/beta Receptor alpha; IFN beta receptor; Interferon alpha/beta receptor 1; IFN-alpha/beta receptor 1; IFN-R-1; IFNAR; IFNAR1; IFNBR; IFRC; INAR1_HUMAN; Interferon (alpha beta and omega) receptor 1; Interferon alpha/beta receptor 1; Interferon alpha/beta receptor alpha chain; Interferon beta receptor 1; Type I interferon receptor 1.

规格价格 100ul/2980元购买        大包装/询价

说明书 100ul

研究领域染色质和核信号  信号转导  细胞因子  表观遗传学

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Pig, Horse,

产品应用 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 61kDa

性    状 Lyophilized or Liquid

浓    度 1mg/ml

免疫原 KLH conjugated synthesised phosphopeptide derived from human IFNAR1 around the phosphorylation site of Tyr466

亚    型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品介绍 background:
IFNAR1 is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.

Function:
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.

Subunit:
Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2.

Subcellular Location:
Isoform 1: Membrane; Single-pass type I membrane protein.

Tissue Specificity:
IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.

Post-translational modifications:
Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.
Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.

Similarity:
Belongs to the type II cytokine receptor family.
Contains 3 fibronectin type-III domains.

Database links:
Entrez Gene: 3454 Human

Omim: 107450 Human

SwissProt: P17181 Human

Unigene: 529400 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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英文名称	Anti-phospho-IFNAR1(Tyr466) /FITC
中文名称	FITC标记的磷酸化干扰素alpha/beta 受体1蛋白抗体
别名	IFNAR1 (phospho Y466); p-IFNAR1 (phospho Y466); Alpha type antiviral protein; AVP; Beta type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; IFN alpha REC; IFN alpha REC; IFN alpha receptor; IFN alpha/beta Receptor alpha; IFN beta receptor; Interferon alpha/beta receptor 1; IFN-alpha/beta receptor 1; IFN-R-1; IFNAR; IFNAR1; IFNBR; IFRC; INAR1_HUMAN; Interferon (alpha beta and omega) receptor 1; Interferon alpha/beta receptor 1; Interferon alpha/beta receptor alpha chain; Interferon beta receptor 1; Type I interferon receptor 1.
规格价格	100ul/2980元购买大包装/询价
说明书	100ul
研究领域	染色质和核信号信号转导细胞因子表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Pig, Horse,
产品应用	ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	61kDa
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthesised phosphopeptide derived from human IFNAR1 around the phosphorylation site of Tyr466
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: IFNAR1 is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Function: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Subunit: Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2. Subcellular Location: Isoform 1: Membrane; Single-pass type I membrane protein. Tissue Specificity: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. Post-translational modifications: Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2. Similarity: Belongs to the type II cytokine receptor family. Contains 3 fibronectin type-III domains. Database links: Entrez Gene: 3454 Human Omim: 107450 Human SwissProt: P17181 Human Unigene: 529400 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.