Recombinant Escherichia coli Transcriptional regulatory protein phoP(phoP)

host_species:Mammalian cell

purification:Greater than 90% as determined by SDS-PAGE.

other_names:

accession_no:P23836

calculated_mw:29.5 kDa

tag info:N-terminal 10xHis-tagged and C-terminal Myc-tagged

Immunogen Description:Expression Region:1-223aa
Sequence Info:Full Length

formulation:Tris-based buffer50% glycerol

storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃,-80℃. The shelf life of lyophilized form is 12 months at -20℃,-80℃.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

background:Member of the two-component regulatory system PhoP,PhoQ involved in adaptation to low Mg2+ environments and the control of acid resistance genes. In low periplasmic Mg2+, PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg2+, PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA,rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes.

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