货号： 130-110-308 CAS号： 130-110-308 供应商： 科敏商城 数量： 大量 英文名： CD16-VioBright 515/CD16 antibodies, human 保质期： 见说明书 保存条件： 见说明书
品Pai:miltenyi，产品名称：CD16-VioBright 515, human
CD16 antibodies, human - Miltenyi Biotec
货号：130-110-308
Clone REA423 recognizes the human CD16 antigen, a single-pass type I membrane protein which is also known as low affinity immunoglobulin gamma Fc region receptor III (FcRIII). CD16 is a 50–80 kDa glycoprotein that is expressed in two different isoforms. The transmembrane form is found on human NK cells, macrophages, and mast cells, while the glycosylphosphatidylinositol (GPI)-linked form is present on neutrophils. The human CD16 antigen is a low-affinity receptor for aggregated IgG. The transmembrane form plays a role in signal transduction, NK cell activation, and antibody-dependent cellular cytotoxicity. Clone REA423 recognizes both the extracellular domain of the transmembrane form as well as the GPI-linked form of the human CD16 antigen. CD16 is expressed on the majority of rhesus monkey NK cells and on a subset of monocytes but not on granulocytes.
Additional information: Clone REA423 displays negligible binding to Fc receptors.
| Clone | Isotype |
|---|---|
| REA423 | recombinant human IgG1 |
CD16-VioBright 515/CD16 antibodies, human
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