CD44-VioBright FITC/CD44 antibodies, mouse

品Pai:miltenyi，产品名称：CD44-VioBright FITC, mouse
CD44 antibodies, mouse - Miltenyi Biotec
货号：130-110-087
Clone REA664 recognizes the mouse CD44 antigen, which is also known as Pgp-1, HCELL, HUTCH-I, HCAM, HERMES, and Ly-24. CD44 is a 80–95 kDa membrane glycoprotein and expressed by a variety of hematopoetic and non-hematopoetic cells. Different isoforms are generated by alternative splicing. Clone REA664 reacts with all isoforms and both allelic forms of CD44. CD44 functions as a receptor for hyaluronic acid (HA) and mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). The interaction between galectin-9 and CD44 increases the stability and function of adaptive regulatory T cells. CD44 expression is upregulated on naive T cells upon activation and high CD44 expression is maintained on memory T cells. Therefore, CD44 is often used to discriminate CD44^hi antigen–experienced T cells from CD44^low (CD62L⁺) naive T cells.
Additional information: Clone REA664 displays negligible binding to Fc receptors.

Alternative namesCD44s, EMCR III, H-CA, Pgp-1, HERMES, Ly-24, HUTCH-I, Hermes antigen

Clone and isotype

Clone	Isotype
REA664	recombinant human IgG1