PIR-A/B-Biotin/Anti-PIR-A/B antibodies, mouse

品Pai:miltenyi，产品名称：Anti-PIR-A/B-Biotin, mouse 200 tests
Anti-PIR-A/B antibodies, mouse - Miltenyi Biotec
货号：130-106-960
Clone REA472 recognizes both isoforms of the mouse paired immunoglobulin-like receptor (PIR-A and PIR-B) antigen, a single-pass type I membrane protein which is also known as leukocyte immunoglobulin-like receptor 3 (LIR-3). Cell surface expression of PIR molecules on myeloid and B lineage cells increase with cellular differentiation and activation. PIR molecules are also expressed on dendritic cells, monocytes/macrophages, and mast cells in varying levels, but not on T cells and NK cells. PIR-A/B is a receptor for class I MHC antigens and down-regulates antigen-induced B cell–activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
Additional information: Clone REA472 displays negligible binding to Fc receptors.

Alternative names6M21, Ly89, PIRA1, Pir, GP91, LIR-3, LILRB3, PIR-B

Clone and isotype

Clone	Isotype
REA472	recombinant human IgG1