Siglec-5/Sig-14-APC/Anti-Siglec-5/Siglec-14 antibodies, human

品Pai:miltenyi，产品名称：Anti-Siglec-5/Sig-14-APC, human
Anti-Siglec-5/Siglec-14 antibodies, human - Miltenyi Biotec
货号：130-106-019
Clone REA393 recognizes the human siglec-5 and siglec-14 antigens, which are both single pass transmembrane protein members of the immunoglobulin superfamily. Siglec-5 is also known as CD170. Siglec-5 has four extracellular Ig-like domains and a cytosolic inhibitory motif. Siglec-14 was discovered with three Ig-like domains and has almost complete sequence identity with siglec-5 at the first two Ig-like domains, shows a glycan binding preference similar to that of siglec-5, and associates with the activating adapter protein DAP12. Siglec-5 is expressed on granulocytes and monocytes as well as on plasmacytoid dendritic cells, monocyte-derived dendritic cells, and macrophages. It is potentially involved in the negative regulation of innate immune responses, and also suggested to be a useful diagnostic and therapeutic marker for acute myelogenous leukemia. Siglec-14 is expressed on granulocytes and B cells. Some individuals lack the expression of siglec-14, while they all express siglec-5.
Additional information: Clone REA393 displays negligible binding to Fc receptors.

Alternative namesCD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14

Clone and isotype

Clone	Isotype
REA393	recombinant human IgG1