HLA-B7/Anti-HLA-B7, B27 antibodies, human

品Pai:miltenyi，产品名称：Anti-HLA-B7, B27-Biotin, human
Anti-HLA-B7, B27 antibodies, human - Miltenyi Biotec
货号：130-105-997
Clone REA176 recognizes HLA B7 and B27, class I human leukocyte antigens (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of 3 domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8-10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. HLA-B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies. HLA-B27 is known for its strong association with inflammatory spondyloarthropathies. It has been also discovered as a protective factor against some severe viral infections.
Additional information: Clone REA176 displays negligible binding to Fc receptors.

Alternative namesHLA-B, AS, SPDA1

Clone and isotype

Clone	Isotype
REA176	recombinant human IgG1