CD62P-PE-Vio770/CD62P antibodies, human

品Pai:miltenyi，产品名称：CD62P-PE-Vio770, human
CD62P antibodies, human - Miltenyi Biotec
货号：130-105-669
Clone REA389 recognizes the human CD62P antigen, a 140 kD single-pass type I membrane protein also known as P-selectin or platelet activation dependent granule-external membrane protein (PADGEM). CD62P is expressed by vascular endothelial cells and platelets. The protein is stored preformed in the Weibel-Palade bodies of endothelial cells and in the α-granules of platelets. Upon stimulation of these cells with a variety of agonists such as thrombin or histamine, P-selectin is rapidly translocated to the cell surface, where it mediates leukocyte-platelet and leukocyte-vascular endothelial cell adhesion. The interaction of P-selectin with mature leukocytes is in part responsible for mediating leukocyte rolling on vascular cells – an early event in leukocyte recruitment at sites of inflammation. In addition to its role as a receptor for mature neutrophils and monocytes, P-selectin also functions as a cell adhesion molecule for leukocyte precursor cells in the bone marrow, including both lineage-restricted clonogenic progenitors and hierarchically more primitive progenitor cells.
Additional information: Clone REA389 displays negligible binding to Fc receptors.

Alternative namesSELP, CD62, GMP-140, GRMP, LECAM3, PADGEM, PSEL, P-selectin

Clone and isotype

Clone	Isotype
REA389	recombinant human IgG1