CD230 (PrP)-Biotin/CD230 (PrP) antibodies, human

品Pai:miltenyi，产品名称：CD230 (PrP)-Biotin, human
CD230 (PrP) antibodies, human - Miltenyi Biotec
货号：130-105-066
Clone REA203 recognizes CD230, commonly known as the prion protein (PrP). The normal cellular PrP (PrP^c) is a ubiquitously expressed glycosylphosphatidyl-inositol (GPI) anchored protein. Though the main function of PrP^c remains unknown, it has been suggested that PrP^c may play a role in copper regulation, antioxidant activity, intracellular signaling. PrP^sc is the conformational isoform of PrP^c with similar primary sequence but different tertiary structure and is associated with neurodegenerative diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy, and scrapie in sheeps. PrP^sc is suggested to derive from PrP^c in a posttranslational process which involves PrP^c-PrP^sc molecular interactions.
Additional information: Clone REA203 displays negligible binding to Fc receptors.

Alternative namesPRNP, ASCR, CJD, GSS, KURU, PRIP, PrP, p27-30

Clone and isotype

Clone	Isotype
REA203	recombinant human IgG1