HLA-DR/Anti-HLA-DR, DP, DQ antibodies, human

品Pai:miltenyi，产品名称：Anti-HLA-DR,DP,DQ-Biotin, human
Anti-HLA-DR, DP, DQ antibodies, human - Miltenyi Biotec
货号：130-104-823
Clone REA332 recognizes all major histocompatibility Class (MHC) class II HLA-DR, DP and most DQ antigens. Expressed on the surface of most nucleated cells, MHC class II molecules play an important role in the immune system. They are essential in the defense against infection and are a main consideration in transplantation medicine. In addition to presenting antigenic peptides from predominantly extracellular sources to CD4⁺ T cells, MHC class II molecules also mediate the thymic selection of helper T cells. MHC class II molecules consist of an α and β chain and are transported to endosomal-lysosomal compartments by the invariant chain. In humans, MHC class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display 70% similarity to each other. Despite the essential function of MHC class II molecules in immune defense against pathogens, some alleles are frequently linked to immune diseases.
Additional information: Clone REA332 displays negligible binding to Fc receptors.

Alternative namesHLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DQB3, HLA-DRA, HLA-DRB1

Clone and isotype

Clone	Isotype
REA332	recombinant human IgG1