aERK 1/2 (pT202/pY204)-PerCP-Vio700/Anti-ERK1/2 pT202/pY204 antibodies, human and mouse

品Pai:miltenyi，产品名称：aERK 1/2 (pT202/pY204)-PerCP-Vio700, h&m
Anti-ERK1/2 pT202/pY204 antibodies, human and mouse - Miltenyi Biotec
货号：130-103-620
Clone REA152 recognizes the phosphorylated threonine 202 and tyrosine 204 (pT202/pY204) of human ERK1 and pT184/pY186 of human ERK2, which are key components of the MAPK signaling cascade. ERK1 and ERK2 are multifunctional serine/threonine kinases and are ubiquitously expressed in mammalian cells. They share 85% homology and are phosphorylated by kinases MEK1/2 at Thr and Tyr residues within their activation loop leading to activation and nuclear translocation of ERKs. Activated ERKs phosphorylate downstream targets, such as signaling effectors, receptors, cytoskeletal proteins, and transcription factors. Owing to such a wide array of cellular targets, ERKs are involved in regulation of a number of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription. Activation and mobilization of ERKs is induced in response to several extracellular signals and engagement of receptors such as Tyr kinases (RTKs), G protein–coupled receptors (GPCRs), ion channels, and others. The ERK1/2 are dual specificity kinases and phosphorylate Ser or Thr residues neior to Proline residue.
Additional information: Clone REA152 displays negligible binding to Fc receptors.

Alternative namesMAPK1, MAPK3, ERK, ERK-2, ERK-1

Clone and isotype

Clone	Isotype
REA152	recombinant human IgG1