CD314-Biotin/CD314 (NKG2D) antibodies, mouse

品Pai:miltenyi，产品名称：CD314-Biotin, mouse 200 tests
CD314 (NKG2D) antibodies, mouse - Miltenyi Biotec
货号：130-101-981
Clone CX5 recognizes mouse CD314 (NKG2D), a type II transmembrane homodimeric glycoprotein belonging to the C-type lectin-like receptor family. CD314 in mice is expressed on activated CD8⁺ αβ T cells, NK cells, subsets of γδ T cells, IFN-producing killer dendritic cells, subsets of NKT cells, and activated macrophages. For signaling, CD314 associates with signaling adapters DAP10 and DAP12 and transduces signal via the PI3-kinase pathway and the Syk-Zap70 pathways, respectively. CD314 recognizes multiple ligands, which are either uregulated in response to cellular stresses such as heat shock, infection, and DNA damage or are constitutively expressed, such as on tumor cells. Known ligands of CD314 in mice include murine UL16-binding protein-like transcript (MULTI), H60 family proteins and the five retinoic acid-inducible proteins RAE-1α, β, γ, δ, ε. Interaction of CD314 with its ligands regulates cytotoxic response towards the cells bearing the cognate ligands.

Alternative namesKlrk1, NKG2-D, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member, Nkg2d

Clone and isotype

Clone	Isotype
CX5	rat IgG1κ