CD170 (Siglec-5)-Biotin/CD170 (Siglec-5) antibodies, human

品Pai:miltenyi，产品名称：CD170 (Siglec-5)-Biotin, human
CD170 (Siglec-5) antibodies, human - Miltenyi Biotec
货号：130-101-807
Clone 1A5 recognizes the CD170 antigen, a single pass transmembrane protein member of the immunoglobulin superfamily and is also known as sialic acid-binding Ig-like lectin 5 (Siglec-5). CD170 is expressed on neutrophils, monocytes, dendritic cells, and subsets of tissue macrophages. It contains two tyrosine-based motifs in its cytoplasmic tail implicating signaling functions and forms a 140 kDa dimer on the cell surface. Tyrosine phosphorylation of CD170 leads to recruitment of the tyrosine phosphatases SHP-1 and SHP-2, which in turn efficiently inhibits FcεRI-mediated calcium fluxing and serotonin release. CD170 binds α 2-3- and α 2-6-linked sialic acid as well as glycophorin A, and is involved in cell adhesion.

Alternative namesCD33L2, OB-BP2, OBBP2, Siglec-5

Clone and isotype

Clone	Isotype
1A5	mouse IgG1κ