Granzyme B-PE/Anti-Granzyme B antibodies, human, mouse, rat

品Pai:miltenyi，产品名称：Anti-Granzyme B-PE, human
Anti-Granzyme B antibodies, human, mouse, rat - Miltenyi Biotec
货号：130-101-351
Clone REA226 recognizes granzyme B, a 32 kDa member of serine protease family, which is involved in cell lysis mediated by cytotoxic T lymphocytes (CTLs) and NK cells. Also known as granule enzymes, granzymes comprise majority of the mass of cytolytic granules in cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B is one of the five granzymes expressed by humans. NK cells and γδ T cells express granzymes constitutively, whereas expression in T lymphocytes is stimulation dependent. Main function attributed to granzymes is to indue apoptotic death of infected and transformed cells, where granzyme B enters into the target cell in a perforin dependent manner and via cation-independent mannose-6-phosphate receptor (CI-MPR). Granzyme B cleaves cellular substrates such as procaspase-3 and Bid, which then initiate pathways involved in apoptotic cell death. Granzyme B is suggested to be the only mammalian serine protease that prefers acidic side chains.
Additional information: Clone REA226 displays negligible binding to Fc receptors.

Alternative namesGZMB, CCPI, CGL-1, CSP-B, CTLA-1, CTSGL1, HLP, SECT, Granzyme 2

Clone and isotype

Clone	Isotype
REA226	recombinant human IgG1