CD180 pure funct. grade/CD180 (RP105) antibodies – functional grade, mouse

品Pai:miltenyi，产品名称：CD180 pure funct. grade, mouse
CD180 (RP105) antibodies – functional grade, mouse - Miltenyi Biotec
货号：130-101-182
Clone RP/14 recognizes CD180, a type I transmembrane protein structurally similar to Toll like receptors (TLRs), with the conserved features of TLRs, including a leucine-rich repeat extracellular domain and regions containing conserved cysteines. However, in contrast to TLRs, CD180 lacks a typical TIR domain, containing only 6 to 11 intracytoplasmic amino acids. Antibody mediated ligation of CD180 was shown to induce B cell proliferation and protection from subsequent radiation- or dexamethasone-induced apoptosis. Expression of CD180 is found on mature B cells, monocytes, macrophages and dendritic cells. CD180 activity is dependent on physical association with a molecule called MD-1. In B cells, CD180, together with TLR4, has been shown to induce B cell proliferation in response to LPS. However, in primary myeloid cells and in vivo, CD180 acts as an inhibitor of TLR4 signaling.

Alternative namesLy78, RP105

Clone and isotype

Clone	Isotype
RP/14	rat IgG2aκ