CD278 (ICOS)-APC-Vio770/CD278 (ICOS) antibodies, human, mouse, rat

品Pai:miltenyi，产品名称：CD278 (ICOS)-APC-Vio770, h&m&r
CD278 (ICOS) antibodies, human, mouse, rat - Miltenyi Biotec
货号：130-100-723
Clone REA192 recognizes CD278 (ICOS), which belongs to the CD28 family of proteins. CD28 family members are co-stimulatory receptor molecules, contain single immunoglobulin V-like domain, and belong to the immunoglobulin superfamily. CD287 recognizes ICOSL (inducible T cell co-stimulator ligand) as ligand and its expression is induced on activated T cells. Enhanced expression of CD278 is also observed on T cells, followed by co-stimulation of T cells via CD28. Further expression of CD278 is found on B cells, monocytes, and dendritic cells. Crosslinking of ICOS on T cell surface in the presence of primary stimulation signal leads to T cell proliferation and differentiation. In addition, CD278 plays role in Tʜ cell differentiation, effector T cell function, and isotype class switching.
Additional information: Clone REA192 displays negligible binding to Fc receptors.

Alternative namesICOS, AILIM, CVID1

Clone and isotype

Clone	Isotype
REA192	recombinant human IgG1