Anti-PAX-5 (BSAP) antibodies, human and mouse

品Pai:miltenyi，产品名称：Anti-PAX5 (BSAP)-PE, h&m 30 tests
Anti-PAX-5 (BSAP) antibodies, human and mouse - Miltenyi Biotec
货号：130-099-927
Clone REA140 recognizes PAX-5, which belongs to the paired box (PAX) gene family of transcription factors. PAX-5 is the only mammalian PAX transcription factor, which is expressed in hematopoietic cells. Within the hematopoietic cells, expression of PAX-5 is limited to cells of the B-lymphocyte lineage and it exerts transcriptional control of B cell commitment, development and B cell tumorigenesis. PAX-5 contains DNA binding conserved ‘paired’ domain, which consists of an N- and a C-terminal subdomain. Each subregion contains a homeodomain-like helix-turn-helix motif, which binds to a half-site of the PAX-5 recognition sequence. Depending upon the interaction partners, PAX-5 serves either as an activator or repressor of transcription. For instance, Groucho protein family members, by binding to a conserved octapeptide motif of PAX-5, enable PAX-5 to serve as a repressor. Additional information: Clone REA140 displays negligible binding to Fc receptors.

Alternative namesALL3, BSAP, EBB-1, KLP

Clone and isotype

Clone	Isotype
REA140	recombinant human IgG1