CD49f-Biotin/CD49f antibodies, human and mouse

品Pai:miltenyi，产品名称：CD49f-Biotin, human and mouse
CD49f antibodies, human and mouse - Miltenyi Biotec
货号：130-097-243
Clone GoH3 reacts with CD49f, a 120 kDa transmembrane glycoprotein also known as α6 integrin. Integrins are integral cell-surface proteins composed of an α chain and a β chain and are involved in cell adhesion as well as cell-surface mediated signaling. CD49f associates with integrin β1 chain (CD29) to form VLA-6 and with integrin β4 chain (CD104) to form the α6 β4 complex, which plays a critical structural role in the hemidesmosome and constitutes a receptor for laminin in epithelial cells. CD49f is furthermore expressed on T cells, monocytes, platelets, endothelial cells, trophoblasts of placenta, and spermatogonial stem cells. Clone GoH3 antibody has been reported to block laminin binding in vitro and to block integrin α6 function in vivo.

Alternative namesITGA6, α6 integrin, ITGA6B, VLA-6, CD49f, VLA-6α

Clone and isotype

Clone	Isotype
GoH3	rat IgG2aκ