CD324-PE (E-Cadherin)/CD324 (E-Cadherin) antibodies, human

品Pai:miltenyi，产品名称：CD324-PE (E-Cadherin), human
CD324 (E-Cadherin) antibodies, human - Miltenyi Biotec
货号：130-095-413
CD324, also known as E-Cadherin or cadherin-1, is a calcium dependent cell adhesion protein found in adherence junctions of epithelial cells, e.g., in colon, uterus, liver, keratinocytes etc. E-Cadherin also serves as a ligand for integrin alpha-E/beta-7¹. The epitope is expressed by a variety of carcinoma-derived cell lines such as MCF-7, HT-29, T-47D, NTERA-2, and 2102Ep. Loss of E-Cadherin is thought to enable metastasis by disrupting intercellular contacts—an early step in metastatic dissemination². Furthermore, E-Cadherin is a marker of undifferentiated embryonic stem (ES) cells and induced pluripotent stem (iPS) cells^3,4. For these cells, E-Cadherin plays a major role in conveying cell survival signals⁵.

Alternative namesCDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin

Clone and isotype

Clone	Isotype
67A4	mouse IgG1κ