PSA-NCAM-APC/Anti-PSA-NCAM antibodies, human, mouse, rat

品Pai:miltenyi，产品名称：Anti-PSA-NCAM-APC, human, mouse, rat
Anti-PSA-NCAM antibodies, human, mouse, rat - Miltenyi Biotec
货号：130-093-273
Anti-PSA-NCAM MicroBeads recognize polysialic acid (PSA), which is linked to the extracellular domain of the neural cell adhesion molecule (NCAM, CD56).¹ PSA-NCAM, the highly polysialated form of NCAM, is predominantly expressed in embryonic and neonatal neural tissue.² In adult mammalian brain PSA-NCAM expression is restricted mainly to areas that retain neurogenic potential, such as the subventricular zone (SVZ)³ and the dentate gyrus of the hippocampus.⁴ PSA-NCAM is a marker for immature neuronal-committed progenitors that are permanently generated in the SVZ and migrate along a well-defined pathway, the rostral migratory stream, into the olfactory bulb where they differentiate into GABAergic and dopaminergic interneurons.^3,5 PSA-NCAM positive neuronal precursors have been isolated from rat forebrain and from mouse SVZ tissue in conjunction with prior depletion of A2B5+ glial progenitor cells.^6-10

Alternative namesNCAM1, CD56, MSK39, NCAM, E-NCAM, NCAM-1, NCAM-C

Clone and isotype

Clone	Isotype
2-2B	mouse IgM