Tom20 (D8T4N) (HRP)

品Pai:CST，产品名称：Tom20 (D8T4N) Rabbit mAb (HRP Conjugate) #72610
英文名称：Tom20 (D8T4N) Rabbit mAb (HRP Conjugate)
Product name：Tom20 (D8T4N) Rabbit mAb (HRP Conjugate) #72610
Isotype：Rabbit IgG
Sensitivity：Endogenous
Applications：WB ,
Purification： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human Tom20 protein.
Background： Mitochondria play a central role in cellular energy metabolism and are essential organelles in eukaryotes. In humans, 13 proteins are encoded by the mitochondrial genome while the vast majority of mitochondrial proteins are encoded by the nuclear genome. As a result, most mitochondrial proteins are synthesized as precursors in the cytoplasm and imported across mitochondrial membranes by one or more translocase protein complexes (1). The translocase of the outer mitochondrial membrane (TOM complex) facilitates the import of proteins through the outer mitochondrial membrane, while the complementary translocase of the inner membrane (TIM complex) is responsible for protein transport to the mitochondrial matrix. The TOM complex consists of the receptors Tom20, Tom22, and Tom70, and the channel-forming protein Tom40 (1). Tom20 is localized in the outer mitochondrial membrane and initially recognizes precursors with a presequence to facilitate protein import across the outer mitochondrial membrane (2). In a sequential process, recognition of the presequence by Tom20 is followed by tethering of the presequence to the Tom40 protein complex for efficient protein import (3).

Entrez-Gene Id

Swiss-Prot Acc.

Specificity / Sensitivity:

Tom20 (D8T4N) Rabbit mAb (HRP Conjugate) recognizes endogenous levels of total Tom20 protein.

Species Reactivity:

Human, Mouse, Rat, Monkey

Storage:

Supplied in 136 mM NaCl, 2.6 mM KCl, 12 mM sodium phosphate (pH 7.4) dibasic, 2 mg/ml BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Product Description:

This Cell Signaling Technology antibody is conjugated to the carbohydrate groups of horseradish peroxidase (HRP) via its amine groups. The HRP conjugated antibody is expected to exhibit the same species cross-reactivity as the unconjugated Tom20 (D8T4N) Rabbit mAb #42406.