FITC标记的心房钠尿因子/心钠素/心房利钠肽抗体_详细资料

产品信息

货号： LM-2040R-FITC 保存条件： -20 °C 浓度： 1mg/ml 应用范围： IF=1:50-200 形态：粉末、液体、冻干粉亚型： IGg 免疫原：详见说明书适应物种： Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, 宿主： Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, 标记物： FITC标记抗体名： Anti-Atrial natriuretic factor/FITC 抗体英文名： Anti-Atrial natriuretic factor/FITC 保质期： 1年抗原来源： Rabbit 克隆性：多克隆目录编号： LM-2040R-FITC 级别： 1 靶点：详见说明书数量：大量供应商：上海联迈生物工程有限公司规格： 100ul

FITC标记的心房钠尿因子/心钠素/心房利钠肽抗体

英文名称 Anti-Atrial natriuretic factor/FITC

中文名称 FITC标记的心房钠尿因子/心钠素/心房利钠肽抗体

别    名 Prepronatriodilatin; ANF_HUMAN; Cardiodilatin; ANF; Atrial natriuretic factor; CDD ANF; CDP; PND; Prepronatriodilatin; Nppa; Natriuretic peptides A; Atrial natriuretic peptide; CDD-ANF; ANP.

规格价格 100ul/2980元购买        大包装/询价

说明书 100ul

研究领域心血管  细胞生物  信号转导  激酶和磷酸酶

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,

产品应用 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 3/17kDa

性    状 Lyophilized or Liquid

浓    度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human ANP

亚    型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品介绍 background:
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009].

Function:
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Subunit:
Interacts with NPR1.

Subcellular Location:
Secreted.

Post-translational modifications:
Cleaved by CORIN upon secretion to produce the functional hormone.

DISEASE:
Atrial fibrillation, familial, 6 (ATFB6) [MIM:612201]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the natriuretic peptide family.

Database links:
Entrez Gene: 4878 Human

Entrez Gene: 608289 Dog

Entrez Gene: 230899 Mouse

Omim: 108780 Human

SwissProt: P07499 Dog

SwissProt: P01160 Human

SwissProt: P05125 Mouse

Unigene: 75640 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

心钠素（心房利尿钠肽）：心钠素主要是由心房分泌的一种含有28个氨基酸并由二硫键结合的一环形肽分子，具有强大的利钠、利尿、扩血管等作用。使血管舒张，外周阻力降低；使每博输出量变少，心率减慢；肾排水排钠增多；导致体内细胞外液量减少。
心钠素主要来源于心肌纤维，但脑、肾、肺、肾上腺等器官、组织也能表达，但产生及分泌的方式有一定差异。

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英文名称	Anti-Atrial natriuretic factor/FITC
中文名称	FITC标记的心房钠尿因子/心钠素/心房利钠肽抗体
别名	Prepronatriodilatin; ANF_HUMAN; Cardiodilatin; ANF; Atrial natriuretic factor; CDD ANF; CDP; PND; Prepronatriodilatin; Nppa; Natriuretic peptides A; Atrial natriuretic peptide; CDD-ANF; ANP.
规格价格	100ul/2980元购买大包装/询价
说明书	100ul
研究领域	心血管细胞生物信号转导激酶和磷酸酶
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
产品应用	IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	3/17kDa
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human ANP
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]. Function: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Subunit: Interacts with NPR1. Subcellular Location: Secreted. Post-translational modifications: Cleaved by CORIN upon secretion to produce the functional hormone. DISEASE: Atrial fibrillation, familial, 6 (ATFB6) [MIM:612201]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the natriuretic peptide family. Database links: Entrez Gene: 4878 Human Entrez Gene: 608289 Dog Entrez Gene: 230899 Mouse Omim: 108780 Human SwissProt: P07499 Dog SwissProt: P01160 Human SwissProt: P05125 Mouse Unigene: 75640 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 心钠素（心房利尿钠肽）：心钠素主要是由心房分泌的一种含有28个氨基酸并由二硫键结合的一环形肽分子，具有强大的利钠、利尿、扩血管等作用。使血管舒张，外周阻力降低；使每博输出量变少，心率减慢；肾排水排钠增多；导致体内细胞外液量减少。心钠素主要来源于心肌纤维，但脑、肾、肺、肾上腺等器官、组织也能表达，但产生及分泌的方式有一定差异。