英文名称 | Anti-GSTP1/FITC |
中文名称 | FITC标记的谷胱甘肽硫转移酶pi基因/Glutathione S Transferase pi抗体 |
别 名 | Glutathione S-Transferase pi; GST-Pi; DFN7; Gst-P1; FAEES3; Fatty Acid Ethyl Ester Synthase III; Glutathione S Transferase Pi; GST3; GSTP1; GST pi; PI; GSTP1_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 转录调节因子 激酶和磷酸酶 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, |
产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 23kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human GstP1 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Glutathione S-transferases (GSTs) function in the metabolic detoxification of various environmental carcinogens and lipid hydroperoxides. Members of the murine GSTP (glutathione S-transferase pi) family, termed Gstp1 and Gstp2, are linked to drug resistance and are markers for many cancers. Gstp proteins modulate cell signaling by interacting with c-Jun N-terminal kinase (JNK), and may play a protective role in the development of spontaneous tumors. Gstp has been found in substantia nigra and may be associated with reactive oxygen species-induced neurological disorders such as Parkinson’s disease and may additionally protect against endothelial dysfunction induced by tobacco smoke exposure. Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Subunit: Homodimer. Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the GST superfamily. Pi family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain. Database links: Entrez Gene: 2950 Human Omim: 134660 Human SwissProt: P09211 Human Unigene: 523836 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GST-Pi是GST家族中的一种主要的同工酶,广泛存在于全身器官中,尤以肝肾含量高,具有功能。在多种肿瘤中高表达。目前认为是肿瘤细胞产生耐药的一种标记,与肿瘤的耐药(阿霉素、顺铂、环磷酰胺和瘤可宁等)有关。该抗体主要用于细胞耐YF面的研究。 |