货号：
LM-3806R-FITC
保存条件：
-20 °C
浓度：
1mg/ml
应用范围：
IF=1:50-200
形态：
粉末、液体、冻干粉
亚型：
IGg
免疫原：
详见说明书
适应物种：
Human, Mouse, Rat, Pig, Cow, Horse, Guinea Pig, G
宿主：
Human, Mouse, Rat, Pig, Cow, Horse, Guinea Pig, G
标记物：
FITC标记
抗体名：
Anti-PGP9.5/FITC
抗体英文名：
Anti-PGP9.5/FITC
保质期：
1年
抗原来源：
Rabbit
克隆性：
多克隆
目录编号：
LM-3806R-FITC
级别：
1
靶点：
详见说明书
数量：
大量
供应商：
上海联迈生物工程有限公司
规格：
100ul
FITC标记的神经细胞胞浆蛋白9.5/蛋白基因产物9.5抗体 | 英文名称 | Anti-PGP9.5/FITC |
| 中文名称 | FITC标记的神经细胞胞浆蛋白9.5/蛋白基因产物9.5抗体 |
| 别 名 | Gracile axonal dystrophy; Neuron cytoplasmic protein 9.5; Park 5; Park5; Parkinson Disease 5; PGP 9.5; PGP9.5; PGP95; Protein gene product 9.5; Ubiquitin C terminal esterase L1; Ubiquitin C terminal hydrolase (neuron specific); Ubiquitin C terminal hydrolase; Ubiquitin carboxyl terminal esterase L1; Ubiquitin carboxyl terminal hydrolase isozyme L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin thioesterase L1; Ubiquitin thiolesterase; Ubiquitin thiolesterase L1; UCH L1; UCH-L1; UCHL1; UCHL1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Guinea Pig, G |
| 产品应用 | IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PGP95 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background:
catalyzes the hydrolysis of ubiquitin carboxy-terminal thiolesters to form ubiquitin and a thiol; may play a role in neuropathic pain [RGD].
Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
Function:
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Subcellular Location:
Cytoplasm. Endoplasmic reticulum membrane. About 30% of total UCHL1 is associated with membranes in brain.
Tissue Specificity:
Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
Post-translational modifications:
O-glycosylated.
DISEASE:
Defects in UCHL1 are the cause of Parkinson disease type 5 (PARK5) [MIM:613643]; also known as Parkinson disease autosomal dominant 5. PARK5 is a complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia.
Similarity:
Belongs to the peptidase C12 family.
Database links: Entrez Gene: 7345 Human Entrez Gene: 22223 Mouse Entrez Gene: 396637 Pig Entrez Gene: 29545 Rat Entrez Gene: 101117250 Sheep Entrez Gene: 325119 Zebrafish Omim: 191342 Human SwissProt: P09936 Human SwissProt: Q9R0P9 Mouse SwissProt: Q6SEG5 Pig SwissProt: Q00981 Rat Unigene: 518731 Human Unigene: 29807 Mouse Unigene: 107213 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
该抗原是一种神经特异性蛋白，广泛分布于与外周神经系统的神经元和神经纤维、神经内分泌细胞、肾小管段、睾丸精原细胞、Leydig细胞、卵细胞以及妊娠与非妊娠黄体内的某些细胞。用于标记神经元，对研究几种人慢性神经变性性疾病中广泛存在的细胞包涵体特征较有意义。 |
FITC标记的神经细胞胞浆蛋白9.5/蛋白基因产物9.5抗体
神经细胞蜡样质脂褐质沉积病蛋白CLN5 / 神经细胞蜡样质脂褐质沉积病蛋白CLN5抗体
神经细胞膜糖蛋白M6a / 神经细胞膜糖蛋白M6a抗体
神经细胞囊泡循环蛋白4 / 神经细胞囊泡循环蛋白4抗体
