FITC标记的P21蛋白激活的蛋白激酶6抗体_详细资料

产品信息

货号： LM-4153R-FITC 保存条件： -20 °C 浓度： 1mg/ml 应用范围： IF=1:50-200 形态：粉末、液体、冻干粉亚型： IGg 免疫原：详见说明书适应物种： Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 宿主： Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 标记物： FITC标记抗体名： Anti-PAK6/FITC 抗体英文名： Anti-PAK6/FITC 保质期： 1年抗原来源： Rabbit 克隆性：多克隆目录编号： LM-4153R-FITC 级别： 1 靶点：详见说明书数量：大量供应商：上海联迈生物工程有限公司规格： 100ul

FITC标记的P21蛋白激活的蛋白激酶6抗体

英文名称 Anti-PAK6/FITC

中文名称 FITC标记的P21蛋白激活的蛋白激酶6抗体

别    名 CDKN1A activated kinase 6; Serine/threonine-protein kinase PAK 6; p21 activated protein kinase 6; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A) activated kinase 6; p21-ACTIVATED KINASE 6; p21activated kinase 6; PAK 5; PAK 6; PAK5; Serine threonine protein kinase PAK 6; Serine/threonine protein kinase PAK 6; Serine/threonine protein kinase PAK6; EC 2.7.1.37; PAK-5; PAK-6; Pak6; PAK6_HUMAN.

规格价格 100ul/2980元购买        大包装/询价

说明书 100ul

研究领域肿瘤  免疫学  信号转导  激酶和磷酸酶

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,

产品应用 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 75kDa

性    状 Lyophilized or Liquid

浓    度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human PAK6

亚    型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品介绍 background:
This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.

Function:
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.

Subunit:
Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B.

Subcellular Location:
Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.

Tissue Specificity:
Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.

Post-translational modifications:
Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 CRIB domain.
Contains 1 protein kinase domain.

Database links:
Entrez Gene: 56924 Human

Omim: 608110 Human

SwissProt: Q9NQU5 Human

Unigene: 513645 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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FITC标记的P21蛋白激活的蛋白激酶6抗体

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英文名称	Anti-PAK6/FITC
中文名称	FITC标记的P21蛋白激活的蛋白激酶6抗体
别名	CDKN1A activated kinase 6; Serine/threonine-protein kinase PAK 6; p21 activated protein kinase 6; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A) activated kinase 6; p21-ACTIVATED KINASE 6; p21activated kinase 6; PAK 5; PAK 6; PAK5; Serine threonine protein kinase PAK 6; Serine/threonine protein kinase PAK 6; Serine/threonine protein kinase PAK6; EC 2.7.1.37; PAK-5; PAK-6; Pak6; PAK6_HUMAN.
规格价格	100ul/2980元购买大包装/询价
说明书	100ul
研究领域	肿瘤免疫学信号转导激酶和磷酸酶
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用	IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	75kDa
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human PAK6
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Function: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. Subunit: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B. Subcellular Location: Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction. Tissue Specificity: Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. Post-translational modifications: Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 CRIB domain. Contains 1 protein kinase domain. Database links: Entrez Gene: 56924 Human Omim: 608110 Human SwissProt: Q9NQU5 Human Unigene: 513645 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.