FITC标记的Wnt信号受体蛋白/Frizzled homolog 1抗体_详细资料

产品信息

货号： LM-6148R-FITC 保存条件： -20 °C 浓度： 1mg/ml 应用范围： Flow-Cyt=1:50-200 IF=1:50-200 形态：粉末、液体、冻干粉亚型： IGg 免疫原：详见说明书适应物种： Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, 宿主： Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, 标记物： FITC标记抗体名： Anti-Frizzled 1/Wnt receptor/FITC 抗体英文名： Anti-Frizzled 1/Wnt receptor/FITC 保质期： 1年抗原来源： Rabbit 克隆性：多克隆目录编号： LM-6148R-FITC 级别： 1 靶点：详见说明书数量：大量供应商：上海联迈生物工程有限公司规格： 100ul

FITC标记的Wnt信号受体蛋白/Frizzled homolog 1抗体

英文名称 Anti-Frizzled 1/Wnt receptor/FITC

中文名称 FITC标记的Wnt信号受体蛋白/Frizzled homolog 1抗体

别    名 Frizzled 1; Frizzled-1; Frizzled homolog 1 (Drosophila); Fz1; FZD1; FzE1; Wnt receptor; FZD1_HUMAN.

规格价格 100ul/2980元购买        大包装/询价

说明书 100ul

研究领域肿瘤  细胞生物  免疫学  细胞周期蛋白

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,

产品应用 Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 63/71kDa

性    状 Lyophilized or Liquid

浓    度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human Frizzled 1

亚    型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品介绍 background:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK3 kinase, nuclear accumulation of beta catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt mediated inactivation of GSK3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt, Wnt5B, Wnt6, Wnt7A or Wnt7B.

Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt, Wnt5B, Wnt6, Wnt7A or Wnt7B.

Subcellular Location:
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity).

Tissue Specificity:
Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney.

Similarity:
Belongs to the G-protein coupled receptor Fz/Smo family.
Contains 1 FZ (frizzled) domain.

Database links:
Entrez Gene: 7855 Human

Entrez Gene: 14367 Mouse

Entrez Gene: 317674 Rat

Omim: 601723 Human

SwissProt: Q13467 Human

SwissProt: Q9EQD0 Mouse

SwissProt: Q8CHL0 Rat

Unigene: 17631 Human

Unigene: 150813 Mouse

Unigene: 470210 Mouse

Unigene: 24792 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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FITC标记的Wnt信号受体蛋白/Frizzled homolog 1抗体

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英文名称	Anti-Frizzled 1/Wnt receptor/FITC
中文名称	FITC标记的Wnt信号受体蛋白/Frizzled homolog 1抗体
别名	Frizzled 1; Frizzled-1; Frizzled homolog 1 (Drosophila); Fz1; FZD1; FzE1; Wnt receptor; FZD1_HUMAN.
规格价格	100ul/2980元购买大包装/询价
说明书	100ul
研究领域	肿瘤细胞生物免疫学细胞周期蛋白
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
产品应用	Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	63/71kDa
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Frizzled 1
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK3 kinase, nuclear accumulation of beta catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt mediated inactivation of GSK3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt, Wnt5B, Wnt6, Wnt7A or Wnt7B. Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt, Wnt5B, Wnt6, Wnt7A or Wnt7B. Subcellular Location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Tissue Specificity: Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Similarity: Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain. Database links: Entrez Gene: 7855 Human Entrez Gene: 14367 Mouse Entrez Gene: 317674 Rat Omim: 601723 Human SwissProt: Q13467 Human SwissProt: Q9EQD0 Mouse SwissProt: Q8CHL0 Rat Unigene: 17631 Human Unigene: 150813 Mouse Unigene: 470210 Mouse Unigene: 24792 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.