Ac-DEVD-CMK 细胞可渗透和不可逆的caspaseYZ剂 285570-60-7_详细资料

产品信息

货号： C5528 保存条件： -20 供应商：上海恒斐生物科技有限公司 CAS号： 285570-60-7 英文名： Ac-DEVD-CMK 数量：现货规格： 1mg

Ac-DEVD-CMK 细胞可渗透和不可逆的caspaseYZ剂 285570-60-7 货号C5528Ac-DEVD-CMK 细胞可渗透和不可逆的caspaseYZ剂 化学性质

CAS号 285570-60-7 SDF Download SDF

别名 Ac-Asp-Glu-Val-Asp-CMK,Caspase-3 Inhibitor III

化学名 N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide

SMILES CC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)=O)=O

分子式 C₂₁H₃₁ClN₄O₁₁ 分子量 551

溶解性 Soluble in DMSO 储存条件 Store at -20°C

运输条件 SY装：蓝冰运输。
其他可选规格：常温运输或根据您的要求用蓝冰运输。

一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。

Ac-DEVD-CMK 细胞可渗透和不可逆的caspaseYZ剂 产品描述
Ac-DEVD-CMK is a cell-permeable and irreversible caspase-3 inhibitor [1][2][3].
Apoptosis is a process of programmed cell death that occurs in multicellular organisms. Caspase are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. Caspase activation is a major event in apoptosis. Caspase-3 cleaves and activates caspases 6 and 7, and is processed and activated by caspases 8, 9, and 10 [1][2][3].
Ac-DEVD-CMK (Ac-Asp-Glu-Val-Asp-CH2Cl) is a cell-permeable, irreversible and specific caspase-3 inhibitor. In coronary occlusion/reperfusion rat isolated hearts, Ac-DEVD-CMK reduced infarct size (the percentage of infarction 27.8+3.3% vs control 38.5+2.6%), suggesting that caspase inhibition during early reperfusion protected myocardium against lethal reperfusion injury [1]. In BL41 cells, Ac-DEVD-CMK partially inhibited Mn2+-induced apoptosis and PARP cleavage, and partially blocked B cell death by 37% even at 100 μM [2]. Ac-DEVD-CMK significantly blocked neurotoxicity at 24 hr after 1 hr of SIN-1 exposure and also protected against neurotoxicity at 24 hr after 90 min of zinc (75 μM) exposure. Ac-DEVD-CMK completely blocked SIN-1-induced activation of caspase-3 [3].
Ac-DEVD-CMK 细胞可渗透和不可逆的caspaseYZ剂 References:
[1]. Mocanu MM, Baxter GF, Yellon DM. Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br J Pharmacol. 2000 May;130(2):197-200.
[2]. Schrantz N, Blanchard DA, Mitenne F, et al. Manganese induces apoptosis of human B cells: caspase-dependent cell death blocked by bcl-2. Cell Death Differ. 1999 May;6(5):445-53.
[3]. Zhang Y, Wang H, Li J, et al. Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. J Neurosci. 2004 Nov 24;24(47):10616-27.
Ac-DEVD-CMK 细胞可渗透和不可逆的caspaseYZ剂上海恒斐生物现货供应说明书及YZ剂详情请联系上海恒斐生物021-60493872 刘鑫 17317793691（微信同步）QQ845206284

温馨提示：不可用于临床ZL。

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CAS号	285570-60-7	SDF	Download SDF
别名	Ac-Asp-Glu-Val-Asp-CMK,Caspase-3 Inhibitor III
化学名	N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide
SMILES	CC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)=O)=O
分子式	C₂₁H₃₁ClN₄O₁₁	分子量	551
溶解性	Soluble in DMSO	储存条件	Store at -20°C
运输条件	SY装：蓝冰运输。其他可选规格：常温运输或根据您的要求用蓝冰运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。