5MG Sigma A1410-现货 Dactinomycin;Actinomycin D;放线菌素D;更生霉素;现货

英文名:Dactinomycin, Actinomycin D, ACTD中文名: 更生霉素, 放线菌素DCAS: 50-76-0 说明:放线菌素D(Dactinomycin D)又称更生霉素，分子中含有一个苯氧环结构，通过它连接两个等位的环状肽链。此肽链可与DNA分子的脱氧鸟嘌呤发挥特异性相互作用，使dactinomycin D嵌入DNA双螺旋的小沟中，与DNA形成复合体，阻碍RNA多聚酶的功能，YZRNA的合成，特别是mRNA的合成。属于周期非特异性药物。一次静脉注射给药后，很快从血浆消除，多数药物以原形经胆汁和尿液排出。抗瘤谱较窄，用于肾母细胞瘤、绒毛膜上皮癌、横纹肌肉瘤和神经母细胞瘤等。Sigma相关产品资料：Sigma A1410  Actinomycin D  from Streptomyces sp., ~98% (HPLC)Synonym: Actinomycin C1, Actinomycin IV, DactinomycinCAS Number: 50-76-0Linear Formula: C62H86N12O16Molecular Weight: 1255.42Beilstein Registry Number: 605235EC Number: 200-063-6MDL number: MFCD00005033PubChem Substance ID: 24890541DescriptionBiochem/physiol Actions An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.Caution Hygroscopic and light sensitive.性质biological source from Streptomyces sp.assay ~98% (HPLC)form powdercolor red, powder red to orangemp 251-253solubility DMSO: 1 mg/mLethanol: solublestorage temp. 2-8°C