FITC标记的抗酒石酸酸性磷酸酶5型/5型酸性磷酸酶抗体_详细资料

产品信息

货号： LM-6434R-FITC 保存条件： -20 °C 浓度： 1mg/ml 应用范围： IF=1:50-200 形态：粉末、液体、冻干粉亚型： IGg 免疫原：详见说明书适应物种： Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, 宿主： Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, 标记物： FITC标记抗体名： Anti-Tartrate Resistant Acid Phosphatase/FITC 抗体英文名： Anti-Tartrate Resistant Acid Phosphatase/FITC 保质期： 1年抗原来源： Rabbit 克隆性：多克隆目录编号： LM-6434R-FITC 级别： 1 靶点：详见说明书数量：大量供应商：上海联迈生物工程有限公司规格： 100ul

FITC标记的抗酒石酸酸性磷酸酶5型/5型酸性磷酸酶抗体

英文名称 Anti-Tartrate Resistant Acid Phosphatase/FITC

中文名称 FITC标记的抗酒石酸酸性磷酸酶5型/5型酸性磷酸酶抗体

别    名 Type 5 acid phosphatase; Acid phosphatase 5 tartrate resistant; ACP5; PPA5_HUMAN; T5ap; Tartrate resistant acid ATPase; Tartrate resistant acid phosphatase type 5; Tartrate resistant acid phosphatase type 5 precursor; Tartrate-resistant acid ATPase; Tartrate-resistant acid phosphatase type 5; TR AP; TR-AP; TrATPase; Type 5 acid phosphatase.

规格价格 100ul/2980元购买        大包装/询价

说明书 100ul

研究领域肿瘤  细胞生物  免疫学  信号转导

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,

产品应用 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 34kDa

性    状 Lyophilized or Liquid

浓    度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human TRAP/Tartrate Resistant Acid Phosphatase

亚    型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品介绍 background:
Tartrate-resistant acid phosphatase is an iron containing glycoprotein that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. TRAP is the most basic of the acid phosphatases and is the only form not inhibited by L+-tartrate. TRAP is a relatively minor lysosomal enzyme which may be activated in certain pathologies such as Hodgkin’s disease and B- and T-cell leukemias. Receptor activator of NFκB ligand (RANKL) plays an essential role in osteoclast differentiation and activation by increasing the expression of protease osteoclast markers such as TRAP. TRAP has collagenolytic activity and plays a major role in ligament degradation.

Function:
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

Subunit:
Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).

Subcellular Location:
Lysosome.

DISEASE:
Defects in ACP5 are the cause of spondyloenchondrodysplasia with immune dysregulation (SPENCDI) [MIM:607944]. A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. Note=ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease.

Similarity:
elongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

Database links:
Entrez Gene: 54 Human

Entrez Gene: 11433 Mouse

Entrez Gene: 25732 Rat

Omim: 171640 Human

SwissProt: P13686 Human

SwissProt: Q05117 Mouse

SwissProt: P29288 Rat

Unigene: 1211 Human

Unigene: 46354 Mouse

Unigene: 171928 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

抗酒石酸盐酸性磷酸酶(Tartrate-Resistant Acid Phosphatase,TRAP)是破骨细胞功能的重要标志物,它的活性与破骨细胞活性呈正相关.

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英文名称	Anti-Tartrate Resistant Acid Phosphatase/FITC
中文名称	FITC标记的抗酒石酸酸性磷酸酶5型/5型酸性磷酸酶抗体
别名	Type 5 acid phosphatase; Acid phosphatase 5 tartrate resistant; ACP5; PPA5_HUMAN; T5ap; Tartrate resistant acid ATPase; Tartrate resistant acid phosphatase type 5; Tartrate resistant acid phosphatase type 5 precursor; Tartrate-resistant acid ATPase; Tartrate-resistant acid phosphatase type 5; TR AP; TR-AP; TrATPase; Type 5 acid phosphatase.
规格价格	100ul/2980元购买大包装/询价
说明书	100ul
研究领域	肿瘤细胞生物免疫学信号转导
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
产品应用	IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	34kDa
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human TRAP/Tartrate Resistant Acid Phosphatase
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍	background: Tartrate-resistant acid phosphatase is an iron containing glycoprotein that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. TRAP is the most basic of the acid phosphatases and is the only form not inhibited by L+-tartrate. TRAP is a relatively minor lysosomal enzyme which may be activated in certain pathologies such as Hodgkin’s disease and B- and T-cell leukemias. Receptor activator of NFκB ligand (RANKL) plays an essential role in osteoclast differentiation and activation by increasing the expression of protease osteoclast markers such as TRAP. TRAP has collagenolytic activity and plays a major role in ligament degradation. Function: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. Subunit: Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s). Subcellular Location: Lysosome. DISEASE: Defects in ACP5 are the cause of spondyloenchondrodysplasia with immune dysregulation (SPENCDI) [MIM:607944]. A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. Note=ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease. Similarity: elongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. Database links: Entrez Gene: 54 Human Entrez Gene: 11433 Mouse Entrez Gene: 25732 Rat Omim: 171640 Human SwissProt: P13686 Human SwissProt: Q05117 Mouse SwissProt: P29288 Rat Unigene: 1211 Human Unigene: 46354 Mouse Unigene: 171928 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 抗酒石酸盐酸性磷酸酶(Tartrate-Resistant Acid Phosphatase,TRAP)是破骨细胞功能的重要标志物,它的活性与破骨细胞活性呈正相关.