货号：
LM-11502R-FITC
保存条件：
-20 °C
浓度：
1mg/ml
应用范围：
ICC=1:50-200 IF=1:50-200
形态：
粉末、液体、冻干粉
亚型：
IGg
免疫原：
详见说明书
适应物种：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
宿主：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
标记物：
FITC标记
抗体名：
Anti-NENF/FITC
抗体英文名：
Anti-NENF/FITC
保质期：
1年
抗原来源：
Rabbit
克隆性：
多克隆
目录编号：
LM-11502R-FITC
级别：
1
靶点：
详见说明书
数量：
大量
供应商：
上海联迈生物工程有限公司
规格：
100ul
FITC标记的神经源性神经营养因子抗体 | 英文名称 | Anti-NENF/FITC |
| 中文名称 | FITC标记的神经源性神经营养因子抗体 |
| 别 名 | Neudesin; Cell growth inhibiting protein 47; Cell immortalization-related protein 2; CIR2; Nenf; NENF_HUMAN; Neuron derived neurotrophic factor; Neuron-derived neurotrophic factor; SCIRP10; SCIRP10 related protein; Secreted protein of unknown function; Spinal cord injury related protein 10; SPUF; SPUF protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 16kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Neudesin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background:
Neudesin is a 172 amino acid secreted protein that belongs to the cytochrome b5 family and MAPR subfamily. Neudesin possesses neurotrophic activity, which is enhanced by binding to heme, and may contribute to neuronal differentiation and neural cell proliferation. In primary cultured neurons, Neudesin has been observed to activate Akt1 and ERK 1 phosphorylation. Upregulated in immortal cells, Neudesin contains one cytochrome b5 heme-binding domain and is encoded by a gene that maps to human chromosome 1q32.3. Human chromosome 1 spans 260 million base pairs and comprises nearly 8% of the human genome. A large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome, map to chromosome 1.
Function:
Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme.
Subcellular Location:
Secreted > extracellular space.
Similarity:
Belongs to the cytochrome b5 family. MAPR subfamily.
Contains 1 cytochrome b5 heme-binding domain.
Database links: Entrez Gene: 29937 Human Entrez Gene: 66208 Mouse Entrez Gene: 289380 Rat Omim: 611874 Human SwissProt: Q9UMX5 Human SwissProt: Q9CQ45 Mouse SwissProt: Q6IUR5 Rat Unigene: 461787 Human Unigene: 46444 Mouse Unigene: 3355 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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