Acetyl-Hexapeptide-3 , Cosmetic Grade

Name:(Arg6)-Amyloid beta-Protein (1-40);
Sequence(Three Letter):H-Asp-Ala-Glu-Phe-Arg-Arg-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH (trifluoroacetate salt);
Sequence(One Letter):DAEFRRDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV;
Formula:C194H300N54O58S1;
M.W.:4348.91;
Size:1mg,5mg,10mg,50mg,100mg,1g;
Purity:80%,90%,95%,98%,99%;
Storage Temp:Store at -20°C. Keep tightly closed. Store in a cool dry place.;
Reference:Y.Hori et al., J. Biol. Chem., 282, 4916 (2007)K.Ono et al., J. Biol. Chem., 285, 23186 (2010)B.Alies et al., Inorg. Chem., 50, 11192 (2011);
Description:This peptide is the English (H6R) mutation of beta-amyloid, which accelerates fibrillation without increasing protofibril formation. The English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers. The exchange of His6 by Arg influences the structure of the Cu2+ complex formed by Abeta peptides.