Neurotensin, frog

Name:[Lys(Ac)373]-p53 (368-393), p53 K373(Ac), biotin-labeled, human;
Sequence(Three Letter):Biotin-Lys-Gly-Trp-His-Leu-Lys-Ser-Lys-Lys(Ac)-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2(trifluoroacetate salt);
Sequence(One Letter):Biotin-KGWHLKSK-K(Ac)-GQSTSRHKKLMFKTEGPDSD-NH2;
M.W.:3610.2;
Size:1mg,5mg,10mg,50mg,100mg,1g;
Purity:80%,90%,95%,98%,99%;
Storage Temp:Store at -20°C. Keep tightly closed. Store in a cool dry place.;
Reference:Kubbutat, M. et al. Lett Nature 387, 299 (1997)Li, M. et al. J Biol Chem 277, 50607 (2002);
Description:This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with acetylation at Lys373 and additional KGW residues on its N-terminus. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo.