GSK3 Peptide Substrate

Name:[Cit26]-Histone H3 (21-44)-GGK(Biotin);
Sequence(Three Letter):H-Ala-Thr-Lys-Ala-Ala-Cit-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys-Lys-Pro-His-Arg-Tyr-Arg-Pro-Gly-Gly-Gly-Lys(Biotin)-OH (trifluoroacetate salt);
Sequence(One Letter):ATKAA-Cit-KSAPATGGVKKPHRYRPGGG-K(Biotin);
M.W.:2975.5;
Size:1mg,5mg,10mg,50mg,100mg,1g;
Purity:80%,90%,95%,98%,99%;
Storage Temp:Store at -20°C. Keep tightly closed. Store in a cool dry place.;
Reference:Cuthbert, G. et al. Cell 118, 545 (2004);
Description:This peptide is the fragment of Histone H3 (21-44) with deimination at Arg26, converting it to Cit (citrulline). It is biotinylated through a C-terminal GGK linker. Deimination by peptidyl arginine deiminase 4 (PADI4) blocks methylation by the CARM1 methyltransferase and inhibits transcriptional activation.