Amyloid Precursor Frameshift Mutant C-Term

Name:α-Defensin 6;
Sequence(Three Letter):Ala-Phe-Thr-Cys-His-Cys-Arg-Arg-Ser-Cys-Tyr-Ser-Thr-Glu-Tyr-Ser-Tyr-Gly-Thr-Cys-Thr-Val-Met-Gly-Ile-Asn-His-Arg-Phe-Cys-Cys-Leu(Cys4 and Cys31/Cys6 and Cys20/Cys10 and Cys30 Bridge);
Sequence(One Letter):AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL(Cys4 and Cys31/Cys6 and Cys20/Cys10 and Cys30 Bridge);
Formula:C156H228N46O46S7;
M.W.:3708.27;
Size:1mg,5mg,10mg,50mg,100mg,1g;
Purity:80%,90%,95%,98%,99%;
Storage Temp:Store at -20°C. Keep tightly closed. Store in a cool dry place.;
Chemical bridge:(Cys4 and Cys31/Cys6 and Cys20/Cys10 and Cys30 Bridge);
Reference:Z.Wu et al., J. Pept. Res., 64, 118 (2004) M.J.Nam et al., J. Biol. Chem., 280, 8260 (2005) E.Hazrati et al., J. Immunol., 177, 8658 (2006) A.Szyk et al., Protein Sci., 15, 2749 (2006) M.E.Klotman et al., J. Immunol., 180, 6176 (2008);
Description:Cysteine-rich cationic peptide with antiviral activity against HSV infection and a role in N. gonorrhoeae-mediated HIV enhancement. In contrast to the other members of the ?-defensin family it shows very low antimicrobial activity against Gram-negative and Gram-positive bacteria. As a biomarker of colon adenocarcinoma it may have utility in colon cancer screening and diagnosis.