phospho-GABBR1 (Ser923)磷酸化gamma氨基丁酸B型受体1抗体_详细资料

产品信息

货号： LM-5358R 保存条件： Store at -20 °C 浓度： 1mg/ml 应用范围： WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）形态： Lyophilized or Liquid 亚型： IgG 免疫原： KLH conjugated Synthesised phosphopeptide derived from human GABBR1 around the phosphorylation site of Ser923:R(p-S)RR 适应物种： Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, 宿主： Rabbit 抗体名：磷酸化gamma氨基丁酸B型受体1抗体抗体英文名： phospho-GABBR1 (Ser923) 保质期： 1年抗原来源： Rabbit 克隆性：多克隆目录编号： LM-5358R 数量：大量供应商：上海联迈生物工程有限公司规格： 100ul

phospho-GABBR1 (Ser923)磷酸化gamma氨基丁酸B型受体1抗体

英文名称 phospho-GABBR1 (Ser923)

中文名称磷酸化gamma氨基丁酸B型受体1抗体

别    名 GABBR1 (phospho S1180); GABBR1 (phospho Ser1180); p-GABBR1 (Ser1180); GABAb Receptor 1; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GAB B R1; GABA B R1; GABAB R1; GABAB subunit 1c; GABAB(1e); GABABR 1; GABABR1; GABB R1; GABBR 1; GABBR1 3; GABBR1; Gamma aminobutyric acid (GABA) B receptor 1; Gamma aminobutyric acid B receptor 1; Gamma aminobutyric acid type B receptor subunit 1; Gb 1; Gb1; GPRC 3A; GPRC3A; hGB1a; GABR1_HUMAN; Gamma-aminobutyric acid type B receptor subunit 1; GABA B Receptor 1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1; Seven transmembrane helix receptor.

规格价格 100ul/1580元购买        大包装/询价

说明书 100ul

产品类型磷酸化抗体

研究领域免疫学  神经生物学  细胞膜受体

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,

产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

细胞定位细胞膜分泌型蛋白

性    状 Lyophilized or Liquid

浓    度 1mg/ml

免疫原 KLH conjugated Synthesised phosphopeptide derived from human GABBR1 around the phosphorylation site of Ser923:R(p-S)RR

亚    型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

产品介绍 background:
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009].

Function:
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen.
Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

Subunit:
Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. Isoform 1E: Secreted (Probable).

Tissue Specificity:
Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.

Similarity:
Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
Contains 2 Sushi (CCP/SCR) domains.

SWISS:
Q9UBS5

Gene ID:
2550

Database links:
Entrez Gene: 2550 Human

Entrez Gene: 54393 Mouse

Entrez Gene: 81657 Rat

Omim: 603540 Human

SwissProt: Q9UBS5 Human

SwissProt: Q9WV18 Mouse

SwissProt: Q9Z0U4 Rat

Unigene: 167017 Human

Unigene: 32191 Mouse

Unigene: 30059 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

g-氨基丁酸(GABA)是哺乳动物神经系统中重要的YZ性神经递质，在体内通过作用于离子通道型的GABAA、GABAC受体及代谢型的GABAB受体而发挥生理功能。 GABAB1受体存在于神经元的突触前及突触后部位，介导慢的YZ性效应，在脑内参与许多重要的生理活动和病理变化，包括认知损害、癫痫、痉挛及药物成瘾等。GABAB受体属于G蛋白偶联受体家族的C家族，具有七次跨膜结构，N-端位于胞外，C-端位于胞内。

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英文名称	phospho-GABBR1 (Ser923)
中文名称	磷酸化gamma氨基丁酸B型受体1抗体
别名	GABBR1 (phospho S1180); GABBR1 (phospho Ser1180); p-GABBR1 (Ser1180); GABAb Receptor 1; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GAB B R1; GABA B R1; GABAB R1; GABAB subunit 1c; GABAB(1e); GABABR 1; GABABR1; GABB R1; GABBR 1; GABBR1 3; GABBR1; Gamma aminobutyric acid (GABA) B receptor 1; Gamma aminobutyric acid B receptor 1; Gamma aminobutyric acid type B receptor subunit 1; Gb 1; Gb1; GPRC 3A; GPRC3A; hGB1a; GABR1_HUMAN; Gamma-aminobutyric acid type B receptor subunit 1; GABA B Receptor 1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1; Seven transmembrane helix receptor.
规格价格	100ul/1580元购买大包装/询价
说明书	100ul
产品类型	磷酸化抗体
研究领域	免疫学神经生物学细胞膜受体
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
产品应用	WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
细胞定位	细胞膜分泌型蛋白
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated Synthesised phosphopeptide derived from human GABBR1 around the phosphorylation site of Ser923:R(p-S)RR
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009]. Function: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites. Subunit: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1. Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. Isoform 1E: Secreted (Probable). Tissue Specificity: Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. Similarity: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. Contains 2 Sushi (CCP/SCR) domains. SWISS: Q9UBS5 Gene ID: 2550 Database links: Entrez Gene: 2550 Human Entrez Gene: 54393 Mouse Entrez Gene: 81657 Rat Omim: 603540 Human SwissProt: Q9UBS5 Human SwissProt: Q9WV18 Mouse SwissProt: Q9Z0U4 Rat Unigene: 167017 Human Unigene: 32191 Mouse Unigene: 30059 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. g-氨基丁酸(GABA)是哺乳动物神经系统中重要的YZ性神经递质，在体内通过作用于离子通道型的GABAA、GABAC受体及代谢型的GABAB受体而发挥生理功能。 GABAB1受体存在于神经元的突触前及突触后部位，介导慢的YZ性效应，在脑内参与许多重要的生理活动和病理变化，包括认知损害、癫痫、痉挛及药物成瘾等。GABAB受体属于G蛋白偶联受体家族的C家族，具有七次跨膜结构，N-端位于胞外，C-端位于胞内。