SLC26A3溶质载体家族蛋白26成员3抗体_详细资料

产品信息

保存条件： Store at -20 °C 浓度： 1mg/ml 应用范围： ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）形态： Lyophilized or Liquid 亚型： IgG 免疫原： KLH conjugated synthetic peptide derived from human SLC26A3:101-200/764 <Extracellular> 适应物种： Human 宿主： Rabbit 抗体名：溶质载体家族蛋白26成员3抗体抗体英文名： SLC26A3 保质期： 1年抗原来源： Rabbit 克隆性：多克隆目录编号： LM-19816R 数量：大量供应商：上海联迈生物工程有限公司规格： 100ul  200ul

SLC26A3溶质载体家族蛋白26成员3抗体

英文名称 SLC26A3

中文名称溶质载体家族蛋白26成员3抗体

别    名 Chloride anion exchanger; CLD; Congenital chloride diarrhea; Down regulated in adenoma; Down regulated in adenoma protein; Down-regulated in adenoma; DRA; Protein DRA; S26A3_HUMAN; SLC26A3; Solute carrier family 26 member 3.

规格价格 100ul/1380元购买    200ul/2200元购买    大包装/询价

说明书 100ul  200ul

研究领域肿瘤  细胞生物  信号转导  跨膜蛋白

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human,

产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 84kDa

细胞定位细胞膜

性    状 Lyophilized or Liquid

浓    度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human SLC26A3:101-200/764 <Extracellular>

亚    型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

产品介绍 background:
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008] Orthologsmouse all

Function:
Chloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption.

Subunit:
nteracts with CFTR, SLC26A6 and SLC9A3R1 (By similarity). Interacts with PDZK1.

Subcellular Location:
Apical cell membrane.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

DISEASE:
Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1) [MIM:214700]; also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature.

Similarity:
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Contains 1 STAS domain.

SWISS:
P40879

Gene ID:
126650

Database links:
Entrez Gene: 1811 Human

Entrez Gene: 13487 Mouse

Entrez Gene: 114629 Rat

Omim: 126650 Human

SwissProt: P40879 Human

SwissProt: Q9WVC8 Mouse

SwissProt: Q924C9 Rat

Unigene: 1650 Human

Unigene: 283281 Mouse

Unigene: 81026 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片
Paraformaldehyde-fixed, paraffin embedded (Human liver cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SLC26A3) Polyclonal Antibody, Unconjugated (bs-19816R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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英文名称	SLC26A3
中文名称	溶质载体家族蛋白26成员3抗体
别名	Chloride anion exchanger; CLD; Congenital chloride diarrhea; Down regulated in adenoma; Down regulated in adenoma protein; Down-regulated in adenoma; DRA; Protein DRA; S26A3_HUMAN; SLC26A3; Solute carrier family 26 member 3.
规格价格	100ul/1380元购买 200ul/2200元购买大包装/询价
说明书	100ul 200ul
研究领域	肿瘤细胞生物信号转导跨膜蛋白
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human,
产品应用	ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	84kDa
细胞定位	细胞膜
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human SLC26A3:101-200/764 <Extracellular>
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008] Orthologsmouse all Function: Chloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption. Subunit: nteracts with CFTR, SLC26A6 and SLC9A3R1 (By similarity). Interacts with PDZK1. Subcellular Location: Apical cell membrane. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1) [MIM:214700]; also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Contains 1 STAS domain. SWISS: P40879 Gene ID: 126650 Database links: Entrez Gene: 1811 Human Entrez Gene: 13487 Mouse Entrez Gene: 114629 Rat Omim: 126650 Human SwissProt: P40879 Human SwissProt: Q9WVC8 Mouse SwissProt: Q924C9 Rat Unigene: 1650 Human Unigene: 283281 Mouse Unigene: 81026 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片	Paraformaldehyde-fixed, paraffin embedded (Human liver cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SLC26A3) Polyclonal Antibody, Unconjugated (bs-19816R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.