hair cortex Cytokeratin毛皮质细胞角蛋白/细胞角蛋白40抗体_详细资料

产品信息

货号： LM-16381R 保存条件： Store at -20 °C 浓度： 1mg/ml 应用范围： ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）形态： Lyophilized or Liquid 亚型： IgG 免疫原： KLH conjugated synthetic peptide derived from human hair cortex Cytokeratin:151-250/431 适应物种： Human, Mouse, Dog, Cow, Horse, Sheep, 宿主： Rabbit 抗体名：毛皮质细胞角蛋白/细胞角蛋白40抗体抗体英文名： hair cortex Cytokeratin 保质期： 1年抗原来源： Rabbit 克隆性：多克隆目录编号： LM-16381R 数量：大量供应商：上海联迈生物工程有限公司规格： 100ul  200ul

hair cortex Cytokeratin毛皮质细胞角蛋白/细胞角蛋白40抗体

英文名称 hair cortex Cytokeratin

中文名称毛皮质细胞角蛋白/细胞角蛋白40抗体

别    名 CK-40; Cytokeratin-40; Cytokeratin40; K1C40_HUMAN; Cytokeratin 40; Keratin, type I cytoskeletal 40; Keratin-40; KRT40; Type I hair keratin Ka36.

规格价格 100ul/1380元购买    200ul/2200元购买    大包装/询价

说明书 100ul  200ul

研究领域细胞生物  转运蛋白

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Dog, Cow, Horse, Sheep,

产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 48kDa

细胞定位细胞浆

性    状 Lyophilized or Liquid

浓    度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human hair cortex Cytokeratin:151-250/431

亚    型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

产品介绍 background:
Keratin 40 (KRT40), also known as Cytokeratin-40 (CK-40) or KA36, is a 431 amino acid protein that belongs to the intermediate filament family. As a heterotetramer of two type I and two type II keratins, Keratin 40 may play a role in late hair differentiation. While weakly expressed in tongue, breast, colon and small intestine, Keratin 40 is highly expressed in skin and scalp. The gene that encodes Keratin 40 consists of approximately 9,420 bases and maps to human chromosome 17q21.2. Encoding more than 1,200 genes, chromosome 17 comprises over 2.5% of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, colon, prostate gland and fallopian tubes.

Function:
The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2.

Subunit:
Heterotetramer of two type I and two type II keratins.

Tissue Specificity:
Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level).

Similarity:
Belongs to the intermediate filament family.

SWISS:
Q6A162

Gene ID:
125115

Database links:
Entrez Gene: 125115 Human

Entrez Gene: 406221 Mouse

SwissProt: Q6A162 Human

SwissProt: Q6IFX3 Mouse

Unigene: 534929 Human

Unigene: 422372 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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英文名称	hair cortex Cytokeratin
中文名称	毛皮质细胞角蛋白/细胞角蛋白40抗体
别名	CK-40; Cytokeratin-40; Cytokeratin40; K1C40_HUMAN; Cytokeratin 40; Keratin, type I cytoskeletal 40; Keratin-40; KRT40; Type I hair keratin Ka36.
规格价格	100ul/1380元购买 200ul/2200元购买大包装/询价
说明书	100ul 200ul
研究领域	细胞生物转运蛋白
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Dog, Cow, Horse, Sheep,
产品应用	ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	48kDa
细胞定位	细胞浆
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human hair cortex Cytokeratin:151-250/431
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: Keratin 40 (KRT40), also known as Cytokeratin-40 (CK-40) or KA36, is a 431 amino acid protein that belongs to the intermediate filament family. As a heterotetramer of two type I and two type II keratins, Keratin 40 may play a role in late hair differentiation. While weakly expressed in tongue, breast, colon and small intestine, Keratin 40 is highly expressed in skin and scalp. The gene that encodes Keratin 40 consists of approximately 9,420 bases and maps to human chromosome 17q21.2. Encoding more than 1,200 genes, chromosome 17 comprises over 2.5% of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, colon, prostate gland and fallopian tubes. Function: The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. Subunit: Heterotetramer of two type I and two type II keratins. Tissue Specificity: Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level). Similarity: Belongs to the intermediate filament family. SWISS: Q6A162 Gene ID: 125115 Database links: Entrez Gene: 125115 Human Entrez Gene: 406221 Mouse SwissProt: Q6A162 Human SwissProt: Q6IFX3 Mouse Unigene: 534929 Human Unigene: 422372 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.