Insulin胰岛素抗体_详细资料

产品信息

保存条件： Store at -20 °C 浓度： 1mg/ml 应用范围： WB=1:500-2000 ELISA=1:500-1000 IP=1:20-100 （石蜡切片需做抗原修复）形态： Lyophilized or Liquid 亚型： IgG 免疫原： porcine pancreas ，full length: 适应物种： Human, Mouse, Rat, Pig, 宿主： Rabbit 抗体名：胰岛素抗体抗体英文名： Insulin 保质期： 1年抗原来源： Rabbit 克隆性：多克隆目录编号： LM-0862R 数量：大量供应商：上海联迈生物工程有限公司规格： 50ul  100ul  200ul

Insulin胰岛素抗体

英文名称 Insulin

中文名称胰岛素抗体

别    名 ILPR; INS; Insulin A chain; Insulin B chain; Insulin A chain; Insulin precursor; IRDN; Proinsulin; Proinsulin precursor; IDDM2; INS_HUMAN; MODY10.

规格价格 50ul/780元购买    100ul/1380元购买    200ul/2200元购买    大包装/询价

说明书 50ul  100ul  200ul

研究领域肿瘤  心血管  细胞生物  神经生物学  信号转导  细胞凋亡  生长因子和激素  糖尿病  内分泌病  新陈代谢

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Pig,

产品应用 WB=1:500-2000 ELISA=1:500-1000 IP=1:20-100 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 5.77754kDa

细胞定位分泌型蛋白

性    状 Lyophilized or Liquid

浓    度 1mg/ml

免疫原 porcine pancreas ，full length:

亚    型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

产品介绍 background:
Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.

Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

Subunit:
Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Subcellular Location:
Secreted.

DISEASE:
Hyperproinsulinemia, familial (FHPRI) [MIM:176730]: An autosomal dominant condition characterized by elevated levels of serum proinsulin-like material. Note=The disease is caused by mutations affecting the gene represented in this entry.
Diabetes mellitus, insulin-dependent, 2 (IDDM2) [MIM:125852]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Note=The disease is caused by mutations affecting the gene represented in this entry.
Diabetes mellitus, permanent neonatal (PNDM) [MIM:606176]: A rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. Note=The disease is caused by mutations affecting the gene represented in this entry.
Maturity-onset diabetes of the young 10 (MODY10) [MIM:613370]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the insulin family.

SWISS:
P01315

Gene ID:
397415

Database links:

Entrez Gene: 3630 Human
Entrez Gene: 280829 Cow
Entrez Gene: 16333 Mouse
Entrez Gene: 16334 Mouse
Entrez Gene: 24505 Rat
Entrez Gene: 397415 Pig
Omim: 176730 Human
SwissProt: P01308 Human
SwissProt: P01325 Mouse
SwissProt: P01322 Rat
SwissProt: P01315 Pig
Unigene: 272259 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胰岛素（Insulin）是胰岛beta细胞分泌的一种激素，可以减低血糖浓度。此抗体特异性地识别猪胰岛素，并与人的胰岛素有交叉反应，主要用于胰岛细胞瘤的功能性研究。

产品图片

Sample:
Lane1：Islet A lysates at 20ug;
line2,Islet B lysates at 20ug;
Primary: Anti-Insulin (bs-0862R) at 1:300 dilution;
Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution;
Predicted band size:5.8 kD Observed band size:5.8 kD

您可能感兴趣的产品

Insulin胰岛素抗体

产品信息

联系我们

关注我们

英文名称	Insulin
中文名称	胰岛素抗体
别名	ILPR; INS; Insulin A chain; Insulin B chain; Insulin A chain; Insulin precursor; IRDN; Proinsulin; Proinsulin precursor; IDDM2; INS_HUMAN; MODY10.
规格价格	50ul/780元购买 100ul/1380元购买 200ul/2200元购买大包装/询价
说明书	50ul 100ul 200ul
研究领域	肿瘤心血管细胞生物神经生物学信号转导细胞凋亡生长因子和激素糖尿病内分泌病新陈代谢
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Pig,
产品应用	WB=1:500-2000 ELISA=1:500-1000 IP=1:20-100 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	5.77754kDa
细胞定位	分泌型蛋白
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	porcine pancreas ，full length:
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma. Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds. Subcellular Location: Secreted. DISEASE: Hyperproinsulinemia, familial (FHPRI) [MIM:176730]: An autosomal dominant condition characterized by elevated levels of serum proinsulin-like material. Note=The disease is caused by mutations affecting the gene represented in this entry. Diabetes mellitus, insulin-dependent, 2 (IDDM2) [MIM:125852]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Note=The disease is caused by mutations affecting the gene represented in this entry. Diabetes mellitus, permanent neonatal (PNDM) [MIM:606176]: A rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. Note=The disease is caused by mutations affecting the gene represented in this entry. Maturity-onset diabetes of the young 10 (MODY10) [MIM:613370]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the insulin family. SWISS: P01315 Gene ID: 397415 Database links: Entrez Gene: 3630 Human Entrez Gene: 280829 Cow Entrez Gene: 16333 Mouse Entrez Gene: 16334 Mouse Entrez Gene: 24505 Rat Entrez Gene: 397415 Pig Omim: 176730 Human SwissProt: P01308 Human SwissProt: P01325 Mouse SwissProt: P01322 Rat SwissProt: P01315 Pig Unigene: 272259 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胰岛素（Insulin）是胰岛beta细胞分泌的一种激素，可以减低血糖浓度。此抗体特异性地识别猪胰岛素，并与人的胰岛素有交叉反应，主要用于胰岛细胞瘤的功能性研究。
产品图片	Sample: Lane1：Islet A lysates at 20ug; line2,Islet B lysates at 20ug; Primary: Anti-Insulin (bs-0862R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution; Predicted band size:5.8 kD Observed band size:5.8 kD