Antithrombin III /SERPINC1 antibody_详细资料

产品信息

保存条件： -20 °C 浓度： 1mg/ml 应用范围： WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 形态：冻干粉或液体亚型： IgG 免疫原： KLH conjugated synthetic peptide derived from human Antithrombin III:141-211/464 适应物种： Human, Mouse, Rat, Pig, Cow, Sheep, 宿主： Rabbit 抗体名：抗凝血酶3抗体抗体英文名： Antithrombin III /SERPINC1 antibody 保质期： 12个月抗原来源： Rabbit 克隆性：多克隆目录编号： kl-1636R 数量：大量供应商：上海康朗生物科技有限公司规格： 100ul 200ul

Antithrombin III /SERPINC1 antibody

中文名称抗凝血酶3抗体

别    名 AntithrombinIII; Antithrombin III; AT 3; AT III; AT3; ATIII; MGC22579; Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1; Serine Proteinase Inhibitor Clade C Member 1; SERPIN C1; Serpin peptidase inhibitor clade C (antithrombin) member 1; SERPINC1; ATH III.

规格价格 100ul/1380元购买    200ul/2200元购买    大包装/询价

说明书 100ul  200ul

研究领域心血管  细胞生物  免疫学  合成与降解

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Pig, Cow, Sheep,

产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 51kDa

细胞定位分泌型蛋白

性    状 Lyophilized or Liquid

浓    度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human Antithrombin III:141-211/464

亚    型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

产品介绍 background:
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009].

Function:
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Subunit:
Forms protease inhibiting heterodimer with TMPRSS7.

Subcellular Location:
Secreted, extracellular space.

Tissue Specificity:
Plasma.

Post-translational modifications:
Phosphorylation sites are present in the extracellular medium.

Similarity:
Belongs to the serpin family.

SWISS:
P01008

Gene ID:
462

Database links:
Entrez Gene: 462 Human

Entrez Gene: 11905 Mouse

Entrez Gene: 304917 Rat

Omim: 107300 Human

SwissProt: P01008 Human

SwissProt: P32261 Mouse

Unigene: 75599 Human

Unigene: 260770 Mouse

Unigene: 204806 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片
Tissue/cell: mouse spleen tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-Antithrombin III Polyclonal Antibody, Unconjugated(bs-1636R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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中文名称	抗凝血酶3抗体
别名	AntithrombinIII; Antithrombin III; AT 3; AT III; AT3; ATIII; MGC22579; Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1; Serine Proteinase Inhibitor Clade C Member 1; SERPIN C1; Serpin peptidase inhibitor clade C (antithrombin) member 1; SERPINC1; ATH III.
规格价格	100ul/1380元购买 200ul/2200元购买大包装/询价
说明书	100ul 200ul
研究领域	心血管细胞生物免疫学合成与降解
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Pig, Cow, Sheep,
产品应用	WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	51kDa
细胞定位	分泌型蛋白
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Antithrombin III:141-211/464
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]. Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Subunit: Forms protease inhibiting heterodimer with TMPRSS7. Subcellular Location: Secreted, extracellular space. Tissue Specificity: Plasma. Post-translational modifications: Phosphorylation sites are present in the extracellular medium. Similarity: Belongs to the serpin family. SWISS: P01008 Gene ID: 462 Database links: Entrez Gene: 462 Human Entrez Gene: 11905 Mouse Entrez Gene: 304917 Rat Omim: 107300 Human SwissProt: P01008 Human SwissProt: P32261 Mouse Unigene: 75599 Human Unigene: 260770 Mouse Unigene: 204806 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片	Tissue/cell: mouse spleen tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Antithrombin III Polyclonal Antibody, Unconjugated(bs-1636R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining